Role of the NF-kappaB pathway in the pathogenesis of human disease states

Current Molecular Medicine
Y Yamamoto, R B Gaynor

Abstract

The NF-kappaB family consists of a group of inducible transcription factors which regulate immune and inflammatory responses and protect cells from undergoing apoptosis in response to cellular stress. A number of signal transduction cascades can activate the NF-kappaB pathway to result in the translocation of the NF-kappaB proteins from the cytoplasm to the nucleus where they activate the expression of specific cellular genes. In this review, we discuss cellular genes which are regulated by NF-kappaB and disease states which are associated with constitutive activation of the NF-kappaB pathway. Strategies to prevent prolonged activation of the NF-kappaB pathway are also discussed.

Citations

Feb 27, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Ji Yeon LeeJae Youl Cho
Jul 17, 2004·Histochemistry and Cell Biology·George L King, Mary R Loeken
Apr 28, 2005·Virchows Archiv : an International Journal of Pathology·Xavier DolcetXavier Matias-Guiu
Sep 28, 2010·Angiogenesis·Shoshana GreenbergerJoyce Bischoff
May 13, 2009·The Journal of Biological Chemistry·Min Lian, Xiaofeng Zheng
Apr 7, 2010·Metabolic Syndrome and Related Disorders·Manuel T Velasquez, James D Katz
Dec 27, 2007·Acta Pharmacologica Sinica·Byung Hun Kim, Jae Youl Cho
Jun 19, 2012·The Journal of Clinical Investigation·Jeremy S TilstraPaul D Robbins
Oct 6, 2009·Biological & Pharmaceutical Bulletin·Chan Hum ParkTakako Yokozawa
Jun 26, 2010·Endocrine-related Cancer·Fazlul H SarkarDejuan Kong
Jun 21, 2008·International Journal of Biological Sciences·Nikolaos PaschosAlexandros E Beris
May 18, 2013·Toxicology and Applied Pharmacology·Soodabeh Saeidnia, Mohammad Abdollahi
Mar 8, 2014·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·E C AguilarJ I Alvarez-Leite
Feb 5, 2013·Journal of Molecular Histology·Margherita SistoMassimo D'Amore
Jan 15, 2015·Expert Opinion on Drug Delivery·Lakshmi Sailaja DuvvuriWahid Khan
Jan 29, 2016·Journal of Crohn's & Colitis·Qiao YuMinhu Chen
Jul 13, 2007·Clinical Neurology and Neurosurgery·Marios G LykissasAlexandros E Beris
Sep 17, 2005·Pharmacotherapy·Nigel J Dagenais, Fakhreddin Jamali
Oct 25, 2011·Expert Opinion on Therapeutic Patents·Roberto Gambari
Oct 27, 2006·Diabetes·Holger SchmidUNKNOWN European Renal cDNA Bank (ERCB) Consortium
Jul 19, 2014·Bioscience, Biotechnology, and Biochemistry·Ya Nan SunYoung Ho Kim
Mar 18, 2016·Journal of Biomolecular Structure & Dynamics·Krithika S ShankaranVijayalakshmi Mahadevan
Oct 1, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Subhash DwivediRakesh Shukla
Apr 28, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·V Renju Gopal, M Indira
Mar 22, 2007·Analytical Biochemistry·Keiko TonookaMasaaki Kai
Jun 14, 2005·Biochemical Pharmacology·Khosrow Kashfi, Basil Rigas
Oct 1, 2015·Archives of Endocrinology and Metabolism·Rogério de Oliveira-BatistaPatricia Monteiro Seraphim

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