PMID: 7941195Oct 1, 1994Paper

Role of the nitric oxide donor linsidomine chlorhydrate (SIN-1) in the diagnosis and treatment of erectile dysfunction

Urology
M C TrussU Jonas

Abstract

Recently, nitric oxide was shown to be a mediator of penile erection in men and the nitric oxide donor linsidomine chlorhydrate (SIN-1) was introduced as a novel treatment option in patients with erectile dysfunction. We now present our follow-up results with the intracavernous application of SIN-1. One hundred thirteen patients with erectile dysfunction of various etiologies and 10 normal control subjects underwent intracavernous pharmacotesting with 1 mg SIN-1. Of the 113 patients, 71 (62.8%) underwent additional pharmacotesting with a mixture of papaverine (15 mg/mL) and phentolamine (0.5 mg/mL) (P/P). Forty-eight responders to SIN-1 were enrolled in an autoinjection program with this substance. All normal control subjects had full rigid erections lasting 40 to 70 minutes. Of 113 patients, 78 (69%) had responses sufficient for intercourse with SIN-1, and the other 35 patients (31%) demonstrated inadequate responses. All 44 responders to SIN-1 who also received P/P had erections sufficient for intercourse with P/P in doses of 0.25 to 2 mL (mean, 0.6 +/- 0.3 mL). Six patients (13.6%) had prolonged erections with minimal to moderate doses of P/P. From the total of 27 patients who had erections insufficient for intercourse with ...Continue Reading

Citations

Jan 1, 1997·World Journal of Urology·M C TrussU Jonas
Mar 16, 2000·Clinical Endocrinology·A LevyC Gingell
Nov 4, 1998·Postgraduate Medical Journal·N Burns-Cox, C Gingell
May 19, 2006·Expert Opinion on Therapeutic Targets·Arthur L BurnettTrinity J Bivalacqua
May 10, 2013·Expert Review of Clinical Pharmacology·S UckertMatthias Oelke
Aug 29, 2003·Expert Opinion on Investigational Drugs·S UckertU Jonas
Oct 20, 2015·Sexual Medicine Reviews·Uzoma A Anele, Arthur L Burnett
Mar 6, 1999·The Journal of Physiology·A EscrigM Mas
Mar 19, 2003·International Journal of Andrology·Sandra FilippiFabrizio Ledda
Dec 16, 2006·The Journal of Clinical Hypertension·Arthur L Burnett
Jan 1, 1997·The Journal of Urology·A L Burnett
Feb 1, 1996·The Urologic Clinics of North America·G A Broderick
Jun 14, 2001·The Urologic Clinics of North America·S LeungwattanakijW J Hellstrom
Jun 30, 2004·International Journal of Impotence Research·A L Burnett
Jan 29, 2020·Pharmacology & Therapeutics·Emma MitidieriRaffaella Sorrentino
May 4, 2021·Applied Microbiology and Biotechnology·Yu-Ming CaiLiang Yang

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