PMID: 9443089Jan 27, 1998Paper

Role of the nm23-H1 gene in the metastasis of gastric cancer

Journal of Korean Medical Science
B G HwangS I Hong

Abstract

The nm23 gene is now generally accepted as one of the suppressor genes for metastasis in many types of human cancer. To investigate the role of the nm23 gene in gastric cancer, we examined the expression of nm23-H1 mRNA, mutations, and loss of heterozygosity (LOH) of the nm23-H1 gene in gastric cancers. The expression of nm23-H1 mRNA was examined by Northern blot analysis in eight paired sets of specimens. The expression was higher in primary cancer specimens and metastatic lymph nodes than their corresponding normal gastric mucosa in all eight sets of specimens examined, while it was similar between primary cancer specimens and metastatic lymph nodes. The mutations of the nm23-H1 gene were examined in an additional 11 sets of specimens, including eight sets of analysed by Northern blotting, by polymerase chain reaction single-strand conformation polymorphism analysis, no mutation being found in any of the 11 sets of specimens tested. LOH of the nm23-H1 gene was also examined in additional 12 sets of specimens, among which seven (58%) specimens were informative for LOH. LOH was identified in one (14%) out of these seven informative sets. These results suggest that nm23 may not be the metastasis suppressor gene and the alteratio...Continue Reading

Citations

Oct 11, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Choon-Yee Tan, Christina L Chang
Nov 14, 2007·European Journal of Gastroenterology & Hepatology·Barbara GazvodaRadovan Komel
Jul 22, 2018·Scientific Reports·Jae-Jin LeeKong-Joo Lee
Feb 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Harvey I PassSorin Draghici
Mar 24, 2021·Experimental & Molecular Medicine·Bokyung Kim, Kong-Joo Lee

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