Role of the novel gene BZW2 in the development of hepatocellular carcinoma

Journal of Cellular Physiology
Xin JinJinfeng Zhao

Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in adults. Basic leucine zipper and W2 domains 2 (BZW2) is a member of the basic-region leucine zipper (bZIP) superfamily of transcription factors. Here, we found that BZW2 expression was substantially increased in both human HCC tissues and cell lines, which was correlated with the clinical progression of patients with HCC. Silence of BZW2 in HCC cells by infecting with the lentivirus for delivering BZW2 shRNA (short hairpin RNA), prohibits cell progression, as determined by the suppressed cell proliferation, clonality, invasion, and increased cell apoptosis. Furthermore, overexpression of BZW2 promotes drug resistance of HCC cells, as shown by the attenuated suppression of cell viability and invasion following rapamycin (RAPA) treatment. Mechanistically, overexpression (or silence) of BZW2 in HCC cells significantly stimulates (or decreases) the activation of the PI3K/AKT/mTOR signaling pathway, which is responsible for HCC progression. Thus, increased BZW2 expression in HCC can induce HCC progression and drug resistance via stimulating the PI3K/AKT/mTOR pathway, which may represent a new therapeutic target for HCC.

References

Apr 10, 2007·Acta Biochimica Et Biophysica Sinica·Ping'an ZhuLin Song
Apr 12, 2011·Fundamental & Clinical Pharmacology·Ali A AlshatwiAdulaziz A Alsaif
Sep 27, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Wenting CaoZhixia Ye
Dec 13, 2012·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Peng-Zhou LiFei Ye
Dec 7, 2013·Medical Oncology·Jianmei ChenTiehui Hu
Feb 11, 2014·Cell Metabolism·Jing LiJohn Blenis
Dec 4, 2014·Science Signaling·Zhenhuan GuoRonen Zaidel-Bar

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Citations

Oct 24, 2019·Journal of Cellular Physiology·Longping HuangWeiwei Sheng
Jul 11, 2020·Cell·Michael A GilletteUNKNOWN Clinical Proteomic Tumor Analysis Consortium
Sep 17, 2021·Journal of Chemical Information and Modeling·Kazuma Kaitoh, Yoshihiro Yamanishi
Oct 27, 2021·Bioengineered·Linlin ChenJiasheng Zhang

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