Role of the nuclease activities encoded by herpes simplex virus 1 UL12 in viral replication and neurovirulence

Journal of Virology
Hikaru FujiiYasushi Kawaguchi

Abstract

Enzyme-dead mutations in the herpes simplex virus 1 UL12 gene that abolished its endo- and exonuclease activities only slightly reduced viral replication in cell cultures. However, the UL12 null mutation significantly reduced viral replication, suggesting that a UL12 function(s) unrelated to its nuclease activities played a major role in viral replication. In contrast, the enzyme-dead mutations significantly reduced viral neurovirulence in mice, suggesting that UL12 nuclease activities were critical for viral pathogenesis in vivo.

References

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Jun 21, 2013·Journal of Virology·Yuhei MaruzuruYasushi Kawaguchi

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Citations

Aug 23, 2012·PLoS Pathogens·April J SchumacherSandra K Weller
Apr 18, 2014·Journal of Virology·Yuhei MaruzuruYasushi Kawaguchi
Jul 6, 2014·Journal of Virology·Hikaru FujiiYasushi Kawaguchi

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