Role of the nucleus in apoptosis: signaling and execution

Cellular and Molecular Life Sciences : CMLS
Evgeniia A ProkhorovaInna N Lavrik

Abstract

Since their establishment in the early 1970s, the nuclear changes upon apoptosis induction, such as the condensation of chromatin, disassembly of nuclear scaffold proteins and degradation of DNA, were, and still are, considered as the essential steps and hallmarks of apoptosis. These are the characteristics of the execution phase of apoptotic cell death. In addition, accumulating data clearly show that some nuclear events can lead to the induction of apoptosis. In particular, if DNA lesions resulting from deregulation during the cell cycle or DNA damage induced by chemotherapeutic drugs or viral infection cannot be efficiently eliminated, apoptotic mechanisms, which enable cellular transformation to be avoided, are activated in the nucleus. The functional heterogeneity of the nuclear organization allows the tight regulation of these signaling events that involve the movement of various nuclear proteins to other intracellular compartments (and vice versa) to initiate and govern apoptosis. Here, we discuss how these events are coordinated to execute apoptotic cell death.

References

Oct 1, 1994·The Journal of Cell Biology·K Schulze-OsthoffP H Krammer
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·X LiuX Wang
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·J ZhangM Xu
Nov 7, 1998·Nature Genetics·Z G WangP P Pandolfi
Nov 26, 1998·The Journal of Biological Chemistry·P F LambertJ N Brady
Aug 24, 1999·Cell Death and Differentiation·B ZhivotovskyS Orrenius
Jun 3, 2000·Nature Genetics·M NapireiT Möröy
Mar 30, 2001·The Journal of Biological Chemistry·M D MiramarS A Susin
Aug 14, 2001·Journal of Cellular Biochemistry·A M MartelliR Bortul
Nov 21, 2001·Nature Cell Biology·K F Ferri, G Kroemer
May 15, 2002·Human Mutation·Magali OlivierPierre Hainaut
Jun 5, 2002·The Journal of Cell Biology·Michael MorganAndrew Thorburn
Jul 12, 2002·The EMBO Journal·Zehavit GoldbergYgal Haupt
Jan 14, 2003·Nature Immunology·Kohki KawaneShigekazu Nagata
Feb 28, 2003·Nature·Michal GoldbergStephen P Jackson
Apr 1, 2003·Molecular and Cellular Biology·Christian SchwerkDanny Reinberg
Jun 26, 2003·The Journal of Biological Chemistry·Merav Ben-YehoyadaYosef Shaul
Dec 10, 2003·Oncogene·Jordan S Fridman, Scott W Lowe
Feb 19, 2004·Journal of the National Cancer Institute·Carmela GurrieriPier Paolo Pandolfi
Mar 3, 2004·Molecular Cell·Elisa de StanchinaScott W Lowe
Apr 13, 2004·Oncogene·Xavier SaelensPeter Vandenabeele

❮ Previous
Next ❯

Citations

Oct 30, 2016·Journal of Experimental Botany·D LatrasseM Delarue
Feb 18, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zeina HabliHala Gali-Muhtasib
Jun 6, 2017·Drug Development and Industrial Pharmacy·Shaozhi ZhangQiu Yan
Feb 7, 2018·Human & Experimental Toxicology·E Eluka-OkoludohP Muganda
Mar 10, 2018·Journal of Bioenergetics and Biomembranes·Yasin TülüceMustafa Durgun
Jan 26, 2018·International Journal of Cancer. Journal International Du Cancer·Fan ZhangXu Zhang
Nov 22, 2017·International Journal of Food Sciences and Nutrition·Alexandru FilippiMaria-Magdalena Mocanu
Dec 5, 2017·Pharmacognosy Magazine·Ho Yen FongSaiful Anuar Karsani
Nov 11, 2018·Development·Luis Alberto Baena-LopezReuben McGregor
Feb 13, 2018·Oncology Letters·Yuanyi ZhangZhonghui Liu
Aug 17, 2018·Scientific Reports·Evgeniia A ProkhorovaBoris Zhivotovsky
Nov 8, 2018·BioMed Research International·Neida L PellenzMarta M M F Duarte
May 1, 2020·Cell Death Discovery·Liora LindenboimReuven Stein
Jun 28, 2018·Cell Proliferation·Gelina S KopeinaBoris Zhivotovsky
Apr 16, 2018·Neurotoxicity Research·Kamila Siedlecka-KroplewskaZbigniew Kmieć
Dec 2, 2020·International Journal of Molecular Sciences·Pradeep Kumar RajanJuan Sanabria
Feb 13, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Elwira ChrobakStanisław Boryczka
Feb 11, 2021·Cell Death Discovery·Liora LindenboimReuven Stein
May 20, 2021·Analytical Methods : Advancing Methods and Applications·Haifeng WangShuang Wang
Apr 9, 2018·ACS Biomaterials Science & Engineering·Vaishnavi KulkarniKishore Paknikar
Dec 8, 2021·Soft Matter·Christina M CaragineAlexandra Zidovska

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Journal of Structural Biology
J D RobertsonBoris Zhivotovsky
Current Protocols in Cell Biology
Boris Zhivotovsky, S Orrenius
© 2021 Meta ULC. All rights reserved