Role of the p53 tumor suppressor in metabolism

Médecine sciences : M/S
Matthieu LacroixLaurent Le Cam

Abstract

The p53 tumor suppressor is an essential downstream effector of various cellular stress response pathways that is functionally inactivated in most, if not all, tumors. Since its discovery more than 30 years ago, its role in the control of cell proliferation, senescence and cell survival has been widely described. However, growing evidences from several laboratories indicate that p53 has important transcriptional and non-transcriptional functions in the control of metabolism, including the regulation of glycolysis, glutaminolysis or mitochondrial respiration. Originally identified using in vitro cellular models, this previously underestimated role of p53 has been confirmed in vivo in various genetically engineered mouse models. These recent data suggest that p53 functions in various metabolic pathways significantly contribute to its role in adult tissue homeostasis, aging as well as tumor suppression.

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Citations

Sep 20, 2018·Médecine sciences : M/S·Martine Cordier-BussatMarc Billaud
Dec 21, 2013·Médecine sciences : M/S·Sara JaberFranck Toledo
Oct 21, 2015·Médecine sciences : M/S·Olivier Albagli
Aug 17, 2021·Oxidative Medicine and Cellular Longevity·Kamal Fatima ZahraDaniel Timofte

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