Role of the perifornical hypothalamic monoamine neurotransmitter systems in anorectic effects of endotoxin

Neuroendocrinology
Trinka W AdamsonJohnny Porter

Abstract

The cachexia-anorexia syndrome, in which patients suffering from chronic illness lack the desire to eat and experience weight loss, creates a serious clinical problem when patients are attempting to overcome the disease process. Endotoxin (ET) has many actions in the brain and peripheral injections can affect regulation of monoamines in brain areas as diverse as the olfactory lobes and the locus coeruleus. Certainly, ET is involved in the febrile process and it plays a prominent role in the regulation of food intake and maintenance of body weight during chronic illnesses. Monoamine neurotransmitters in specific regions of the hypothalamus also participate in the regulation of food intake and body weight and have been well characterized. In this regard, the hypothalamic perifornical nucleus (PFN) is of interest to our lab due to its role in drug-induced anorexia caused by amphetamines. It is also the most sensitive site in the hypothalamic monoaminergic system that involves dopamine (DA) and epinephrine (EPI). DA antagonist, stereotaxically placed in this site, can stimulate feeding, and specific injections of DA or EPI can result in a 70-90% decrease in food intake, even in food-deprived animals. We have shown in our studies th...Continue Reading

Citations

May 10, 2011·Physiology & Behavior·Luis HernándezPedro Rada
Nov 28, 2012·Biological Psychiatry·John D Salamone, Mercè Correa
Nov 5, 2010·Current Opinion in Supportive and Palliative Care

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