Role of the pituitary and thyroid glands in the decline of minimal O2 consumption with age

The Journal of Clinical Investigation
W D Denckla

Abstract

Resting O2 consumption rate (BMR) or minimal O2 consumption rate (MOC) declines with age. Data are presented that suggest that a newly described function of the pituitary may be responsible for a considerable part of the total 75% decline in the MOC with age. The new function appears to decrease the responsiveness of peripheral tissues to thyroid hormones. Response curves to injected thyroxine indicated that immature rats were three times more responsive to thyroxine than adult rats. All the major endocrine ablations were performed in this and earlier work, and only pituitary ablation (a) restored in adults part of the responsiveness to thyroxine found in immature rats and (b) arrested the normal age-associated decrease in responsiveness to thyroxine in immature rats. Bovine pituitary extracts were found that decreased the responsiveness of immature rats to thyroxine. Experiments with the new pituitary function suggested a possible endocrine mechanism to explain why partial starvation doubled the lifespan for rats only when started before puberty.

References

Aug 1, 1968·Experimental Gerontology·E GutmannB Jakoubek
Apr 1, 1966·The Journal of Clinical Endocrinology and Metabolism·T H OddieD A Fisher
Sep 1, 1966·Canadian Journal of Physiology and Pharmacology·G Goldspink
Mar 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·P Kumaresan, C W Turner
Jan 1, 1967·The Journal of General Physiology·G N Ling, M H Kromash
Aug 1, 1956·Journal of Chronic Diseases·F POPEC M MCCAY
Nov 1, 1962·The Journal of Clinical Investigation·R I GREGERMANS E CROWDER

❮ Previous
Next ❯

Citations

Sep 1, 1989·Aging : Clinical and Experimental Research·R J McCarterJ R McGee
Mar 1, 1977·Mechanisms of Ageing and Development·W D Denckla
Mar 1, 1977·Mechanisms of Ageing and Development·G E Bilder, W D Denckla
Dec 1, 1978·Mechanisms of Ageing and Development·R J ParkerW D Denckla
Sep 1, 1979·Mechanisms of Ageing and Development·M ScottW D Denckla
Mar 1, 1979·Mechanisms of Ageing and Development·P E Segall
Jan 1, 1979·Mechanisms of Ageing and Development·T Makinodan
Mar 1, 1981·Mechanisms of Ageing and Development·S K Puri, L Volicer
Jun 1, 1983·Mechanisms of Ageing and Development·H OokaE Yoshimoto
Feb 1, 1986·Mechanisms of Ageing and Development·H Ooka, T Shinkai
Mar 31, 1990·Mechanisms of Ageing and Development·J T HerlihyH A Bertrand
Aug 13, 1990·Biochimica Et Biophysica Acta·A D Mooradian
Apr 1, 1988·Medical Hypotheses·J Segal
Jan 1, 1980·Experimental Gerontology·K E CheneyR L Walford
Jan 1, 1983·Experimental Gerontology·T Balmagiya, S J Rozovski
Jan 1, 1985·Experimental Gerontology·L Hayflick
Feb 1, 2003·Experimental Gerontology·Gorji MarzbanHermann Katinger
Feb 1, 1979·The New England Journal of Medicine·P E Dans, M R Kerr
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·G N DeMartino, A L Goldberg
Jan 1, 1984·Experimental Aging Research·M Kiang-Ulrich, S M Horvath
Jan 1, 1976·Immunological Communications·G E Bilder
Dec 3, 2014·Experimental Gerontology·A I Bozhkov, Yu V Nikitchenko
Mar 1, 1976·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·R G RudelE Spalten
Oct 1, 1980·Journal of the American Geriatrics Society·S R GambertE M Dagon
Jul 1, 1983·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·S R Gambert
Nov 1, 1979·Clinics in Endocrinology and Metabolism·P J Davis
Aug 7, 2016·Nutrition & Metabolism·Xunxian Liu, Zemin Yao
Jan 1, 1981·Alcoholism, Clinical and Experimental Research·W T SchafferR L Veech
Nov 1, 1984·Alcoholism, Clinical and Experimental Research·R S BrittonY Israel
May 1, 1985·Journal of the American Geriatrics Society·S R Gambert, P D Tsitouras
Jan 1, 1979·Journal of the American Psychoanalytic Association·G Heilbrunn
Feb 10, 1999·Experimental Gerontology·A BartkeR T Bronson
May 5, 1975·Biochemical and Biophysical Research Communications·G W BrittonR C Adelman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.