PMID: 2094909Jan 1, 1990Paper

Role of the prefrontal--thalamic axis in classical conditioning

Progress in Brain Research
D A PowellC M Gibbs

Abstract

The major conclusion to be drawn from the above-described research on the role of the PFCag in classical conditioning is obviously that it plays a primary and perhaps necessary role in the establishment of visceral cues associated with exposure to classical conditioning contingencies. Specifically, these visceral changes appear to be of an inhibitory character. This is significant, since we have postulated that inhibitory cardiac changes invariably accompany initial processing of sensory stimuli for informational value. Such visceral changes are thus not epiphenomena associated with other simultaneously occurring physiological events. A variety of lesion experiments implicate the PFCm as a central structure in this process, since damage to this area greatly attenuates, and in the case of hypothalamic knife cuts, completely eliminates learned bradycardia. Neuroanatomical tract-tracing experiments revealed that the PFCm and lag have direct projections to the NTS and DVM in the dorsomedial medulla and the nucleus ambiguous in the ventral medulla, all of which provide medullary output control of visceral activities. The nucleus ambiguous and DVM have been specifically implicated in vagal control in the rabbit (Ellenberger et al., 1...Continue Reading

Citations

Nov 6, 2018·Frontiers in Systems Neuroscience·Barak F CaracheoJeremy K Seamans
Jun 30, 2006·Psychophysiology·Júlia Weisz, István Czigler
Sep 12, 2015·British Journal of Pharmacology·D C LagattaL B M Resstel
Feb 14, 2003·Journal of Neuroscience Research·Si Yun ShuBrian Leonard
Jan 1, 1994·Experimental Brain Research·S L BuchananD A Powell
Oct 23, 1998·Experimental Aging Research·M A Flaten, D A Powell

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