Role of the preoperative circulating tumor DNA KRAS mutation in patients with resectable pancreatic cancer.

Pharmacogenomics
Shengnan LiHe Ren

Abstract

Aim: The prognosis of resectable pancreatic cancer patients with the same stage of disease is highly variable. The purpose of this study is to establish a scoring system for preoperative screening of resectable patients. Materials & methods: The clinical information and laboratory tests of 105 resectable patients with pancreatic cancer were enrolled and analyzed. Results: The consistency of clinical stage and pathological stage was poor (κ = 0.193; p < 0.003). We performed a comprehensive scoring system with KRAS mutations in circulating tumor DNA (mutKRAS ctDNA) for the resectable patients. Patients with higher scores were more prone to early postoperative recurrence and poorer prognosis. Conclusion: The scoring system can help preoperatively screen out resectable patients who are prone to early postoperative recurrence.

References

Feb 9, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·X G NiP Zhao
Oct 24, 2008·The New England Journal of Medicine·Christos S KarapetisJohn R Zalcberg
Jul 10, 2010·Journal of Biomedicine & Biotechnology·Sylwia JancíkMarián Hajdúch
Aug 7, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Klaus JungAnja Rabien
Nov 16, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Carlos CampsRafael Sirera
Jun 3, 2011·Archives of Pathology & Laboratory Medicine·Seung-Mo HongMichael Goggins
Mar 9, 2012·The New England Journal of Medicine·Marco GerlingerCharles Swanton
May 17, 2012·Cancer Research·Ian A PriorCarla Mattos
Apr 30, 2013·Gastroenterology·Marina Pasca di Magliano, Craig D Logsdon
Aug 26, 2014·World Journal of Gastroenterology : WJG·Ahmet Bilici
Feb 27, 2015·Nature·Nicola WaddellSean M Grimmond
Jun 19, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jean Sebastien FrenelJohann S de Bono
Jun 20, 2015·SpringerPlus·Sobuhi IqbalNutan Kumar Shukla
Aug 12, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David ChuBen Ho Park
Jan 7, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Barbara BournetLouis Buscail
Feb 6, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Safia El MessaoudiAlain R Thierry
Dec 21, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniel PietraszJean-Baptiste Bachet
Mar 8, 2017·Annals of Surgery·Guopei LuoXianjun Yu
Mar 25, 2017·International Journal of Molecular Sciences·John C Chang, Madappa Kundranda
Apr 5, 2017·Journal of the National Cancer Institute·Michela CapelloSamir M Hanash
Dec 8, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M YangW Zhang
Jan 25, 2018·Cancers·Anuhya KommalapatiAmit Mahipal
Sep 22, 2018·Gastroenterology·Vincent BernardHector A Alvarez
Nov 26, 2018·The Journal of Molecular Diagnostics : JMD·Miguel AlcaideRyan D Morin
Jan 9, 2020·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

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