Role of the Receptor for Advanced Glycation End Products in Heat Stress-Induced Endothelial Hyperpermeability in Acute Lung Injury

Frontiers in Physiology
Gengbiao ZhouQiulin Xu

Abstract

To study the role of the receptor for advanced glycation end products (RAGE) in endothelial barrier dysfunction induced by heat stress, to further explore the signal pathway by which RAGE contributes to heat-induced endothelia response, and thereby find a novel target for the clinical treatment of ALI (acute lung injury) induced by heatstroke. This study established the animal model of heatstroke using RAGE knockout mice. We observed the role of RAGE in acute lung injury induced by heatstroke in mice by evaluating the leukocytes, neutrophils, and protein concentration in BALF (Bronchoalveolar lavage fluids), lung wet/dry ratio, histopathological changes, and the morphological ultrastructure of lung tissue and arterial blood gas analysis. To further study the mechanism, we established a heat stress model of HUVEC and concentrated on the role of RAGE and its signal pathway in the endothelial barrier dysfunction induced by heat stress, measuring Transendothelial electrical resistance (TEER) and western blot. RAGE played a key role in acute lung injury induced by heatstroke in mice. The mechanism C-Jun is located in the promoter region of the RAGE gene. C-Jun increased the RAGE protein expression while HSF1 suppressed RAGE protein ...Continue Reading

References

Jan 1, 1990·Acta neurochirurgica. Supplementum·H S Sharma, J Cervós-Navarro
Jun 21, 2002·The New England Journal of Medicine·Abderrezak Bouchama, James P Knochel
Mar 1, 2005·Emergency Medicine Journal : EMJ·G M VargheseD Mathai
Jan 30, 2008·Critical Care : the Official Journal of the Critical Care Forum·Christian BoppMarkus A Weigand
Aug 5, 2008·Respiratory Physiology & Neurobiology·Tapan K MukherjeeJohn R Hoidal
May 30, 2009·Journal of Leukocyte Biology·Ravichandran RamasamyAnn Marie Schmidt
Dec 29, 2009·Journal of Biomedicine & Biotechnology·Hsi-Hsing YangMao-Tsun Lin
Dec 10, 2013·European Journal of Cell Biology·Melanie KappelmannSilke Kuphal
Sep 19, 2015·Scientific Reports·Weijin ZhangXiaohua Guo
Oct 20, 2018·Journal of Cachexia, Sarcopenia and Muscle·Francesca RiuzziRosario Donato

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