PMID: 2483424Jan 1, 1989Paper

Role of the renin-angiotensin system in the regulation of glomerular filtration.

Journal of Cardiovascular Pharmacology
J D SraerR Lacave

Abstract

Angiotensin II (Ang II) controls renal plasma flow, which depends on perfusion pressure and on renal vascular resistances; the glomerular filtration rate of single nephrons (SNGFR) also depends on these two parameters. The glomerulus can synthesize all components of the renin-angiotensin system. Renin is produced by mesangial cells and cells of afferent arterioles, angiotensinogen by mesangial cells, and angiotensin I-converting enzyme (ACE) by endothelial and mesangial cells. Ang II binds to afferent and efferent arterioles and to mesangial cells, which subsequently contract and enhance their production of vasodilator prostaglandins. Ang II participates in the regulation of the SNGFR by acting on arteriolar resistance, on the glomerular capillary surface area, and finally on the ultrafiltration coefficient. The synthesis of renin is initiated when the cAMP concentration increases under the influence of hormones (parathyroid hormone, catecholamines), of mediators (e.g., prostanoids), or of changes in composition of tubular fluid (in sodium, chlorine, or calcium) detected by the macula densa. Moreover, renin synthesis is stimulated by decreases in intracellular calcium concentration. The renin-angiotensin system plays an importa...Continue Reading

Citations

Aug 5, 2016·Pharmacology & Therapeutics·Laura Prieto-GarcíaFrancisco J López-Hernández
Oct 12, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Anastasia G PtinopoulouAnastasios N Lasaridis
Aug 19, 1999·Cell Biochemistry and Function·B UstündagN Ilhan

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