PMID: 6160330Nov 1, 1980Paper

Role of the renin-angiotensin system in isoprenaline-induced vasopressin release

Journal of Cardiovascular Pharmacology
W Knepel, D K Meyer

Abstract

We examined whether the activation of the renin-angiotensin system after intramuscular isoprenaline injection contributes to the simultaneous increase in vasopressin release. Plasma concentrations of vasopressin and angiotensin II were measured in conscious rats using specific radioimmunoassays. Intravenous infusions of angiotensin II caused a dose-dependent increase in vasopressin release. Intravenous infusions of the angiotensin II antagonist saralasin did not diminish the isoprenaline-induced vasopressin release. However, the curve relating the isoprenaline-induced decrease in blood pressure and the concomitant increase in vasopressin levels was shifted to the right and no longer linear in saralasin-treated rats. Nephrectomy diminished the vasopressin release caused by isoprenaline when compared to sham-operation. The correlation between the decrease in blood pressure and the simultaneous vasopressin release was changed in a strikingly similar manner by nephrectomy and by saralasin infusions. It may be concluded that small doses of isoprenaline, which cause only minor decreases in blood pressure, induce vasopressin release via the renin-angiotensin system. However, the contribution of this system to vasopressin release decli...Continue Reading

Citations

Nov 1, 1980·Pflügers Archiv : European journal of physiology·W KnepelG Hertting
Jul 30, 1982·European Journal of Pharmacology·W KnepelG Hertting
Jan 16, 2003·Physiology & Behavior·Edward M Stricker, Alan F Sved
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·W J Lee-KwonD P Brooks
Feb 28, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sean D StockerAlan F Sved
May 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·I OsP Leren
Sep 1, 1981·Physiology & Behavior·J A Hosutt, E M Stricker

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