Role of the RNA-binding protein La in cancer pathobiology.

RNA Biology
Gunhild Sommer, Tilman Heise

Abstract

RNA-binding proteins are important regulators of RNA metabolism and are of critical importance in all steps of the gene expression cascade. The role of aberrantly expressed RBPs in human disease is an exciting research field and the potential application of RBPs as a therapeutic target or a diagnostic marker represents a fast-growing area of research.Aberrant overexpression of the human RNA-binding protein La has been found in various cancer entities including lung, cervical, head and neck, and chronic myelogenous leukaemia. Cancer-associated La protein supports tumour-promoting processes such as proliferation, mobility, invasiveness and tumour growth. Moreover, the La protein maintains the survival of cancer cells by supporting an anti-apoptotic state that may cause resistance to chemotherapeutic therapy.The human La protein represents a multifunctional post-translationally modified RNA-binding protein with RNA chaperone activity that promotes processing of non-coding precursor RNAs but also stimulates the translation of selective messenger RNAs encoding tumour-promoting and anti-apoptotic factors. In our model, La facilitates the expression of those factors and helps cancer cells to cope with cellular stress. In contrast to o...Continue Reading

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Citations

Feb 2, 2021·RNA Biology·Sandy MattijssenRichard J Maraia
Nov 17, 2020·Journal of Molecular Biology·Eleni G KaliatsiConstantinos Stathopoulos
Oct 29, 2021·Biochemical Society Transactions·Cécile Bousquet-Antonelli
Jul 8, 2021·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Vasilios LiapisAlexander H Staudacher

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Methods Mentioned

BETA
sumoylation
acetylation
immunoprecipitation
xenograft
transfection
pull-down

Software Mentioned

mfold
Ensembl

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