Aug 5, 1999

Role of the serotonergic system in the pathogenesis of major depression and suicidal behavior

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
J John Mann

Abstract

Phylogenetically, the serotonergic system is one of the oldest transmitter systems in the brain. Combining a complex and widespread innervation of most cortical and subcortical structures, with over a dozen receptor subtypes, there is a diversity of signaling opportunities and functional roles that explain the association of serotonin with many different types of psychopathological conditions. The role of the serotonergic system in mood disorders and in the predisposition for suicidal behavior are reviewed in this paper. Effects on the serotonergic system underlie the antidepressant action of many types of medications and must be integrated into a neurobiological model of mood disorders.

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Mentioned in this Paper

Pathogenic Aspects
Pathogenesis
Serotonin Measurement
Muscle Innervation, Function
Serotonin
Brain
Receptors, Tryptamine
Nerve Supply
Structure of Cortex of Kidney
Melancholia

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