Sep 19, 2007

Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction

The Journal of Experimental Medicine
Tomasz J GuzikDavid G Harrison

Abstract

Hypertension promotes atherosclerosis and is a major source of morbidity and mortality. We show that mice lacking T and B cells (RAG-1-/- mice) have blunted hypertension and do not develop abnormalities of vascular function during angiotensin II infusion or desoxycorticosterone acetate (DOCA)-salt. Adoptive transfer of T, but not B, cells restored these abnormalities. Angiotensin II is known to stimulate reactive oxygen species production via the nicotinamide adenosine dinucleotide phosphate (NADPH) oxidase in several cells, including some immune cells. Accordingly, adoptive transfer of T cells lacking the angiotensin type I receptor or a functional NADPH oxidase resulted in blunted angiotensin II-dependent hypertension and decreased aortic superoxide production. Angiotensin II increased T cell markers of activation and tissue homing in wild-type, but not NADPH oxidase-deficient, mice. Angiotensin II markedly increased T cells in the perivascular adipose tissue (periadventitial fat) and, to a lesser extent the adventitia. These cells expressed high levels of CC chemokine receptor 5 and were commonly double negative (CD3+CD4-CD8-). This infiltration was associated with an increase in intercellular adhesion molecule-1 and RANTES ...Continue Reading

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Citations

Mentioned in this Paper

Increased T Lymphocyte Production [PE]
Necrosis
Nicotinamide Assay
RAG1 gene
T-Lymphocyte
Morbidity Aspects
Tumor Necrosis Factor-alpha
CD4 Antigens
Adenosine
Cell Motility

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