Role of the thymus in the generation of skin-homing alpha beta and gamma delta virgin T cells

European Journal of Immunology
E A WashingtonR N Cahill

Abstract

Current models of lymphocyte traffic suggest that homing specificities of T cells to tissues such as skin are generated outside the thymus as a result of activation of naive T cells by antigen in lymph nodes. Virgin T cells are thought to home to high endothelial venules in lymph nodes, but are thought to be unable to home to extra-lymphoid tissues such as skin. We used the technique of in situ labeling of the thymus with fluorescein isothiocyanate to examine the homing specificities of authentically naive T cells in vivo, immediately after their export from the thymus. We report that homing specificities for skin as well as lymph node are imprinted on T cells inside the thymus, independent of antigen. We also show that both alpha beta and gamma delta emigrant T cells exhibit homing patterns to skin and lymph nodes which are identical to those of mature T cells. Our findings demonstrate a key role for the thymus in the induction of skin-homing specificities on T cells indicating that skin-homing specificities of T cells are not generated solely outside the thymus as a result of the activation of virgin T cells by antigen. The migration of thymic emigrants to extra-lymphoid tissues within a few hours of leaving the thymus may ha...Continue Reading

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Citations

Jun 1, 1996·Immunology Today·J Westermann, R Pabst
May 18, 2001·Developmental and Comparative Immunology·T ZhaoS J Mentzer
Nov 1, 1996·Veterinary Immunology and Immunopathology·A D NashV M Bowles
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Mar 28, 2017·Cell Host & Microbe·Tiffany C ScharschmidtMichael D Rosenblum
Jan 1, 1995·International Reviews of Immunology·J Sprent

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