Role of the transcriptional coactivators YAP/TAZ in liver cancer.

Current Opinion in Cell Biology
Shihao Zhang, Dawang Zhou

Abstract

Liver cancer, hepatocellular carcinoma (HCC) in particular, is one of the deadliest cancers worldwide. Although the etiologies for liver oncogenesis are relatively well defined, the exact mechanisms leading to cancer development remain elusive. The Hippo signaling pathway, an evolutionarily conserved signaling module, plays critical roles in organ size control and tumorigenesis. The aberrant activation of the transcriptional coactivator YAP or TAZ, downstream effectors of the Hippo signaling pathway, has been implicated in several human cancers including HCC. YAP/TAZ therefore have emerged as an attractive target for cancer therapeutics. In this review, we summarize the recent findings regarding the role of YAP/TAZ in HCC development, and discuss the multifarious mechanisms regulating their activities and their potential contribution to human liver tumorigenesis.

Citations

Jul 6, 2020·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Jianjun WangRunqiu Jiang
Apr 25, 2020·Cells·Heinrich KovarBranka Radic-Sarikas
Mar 4, 2020·Pediatric Blood & Cancer·Xinyan ChenXin Chen
Feb 26, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yan Zhu, Lawrence N Kwong
Jan 8, 2020·Journal of Experimental & Clinical Cancer Research : CR·Dan JinGuoming Su
May 13, 2020·Oncogene·Hossein TabatabaeianYoon Pin Lim
Sep 29, 2020·Clinical and Molecular Hepatology·Yuchen LiuYingzi Yang
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Yuan GuFa-Xing Yu
Nov 25, 2020·Cellular and Molecular Gastroenterology and Hepatology·Haichuan WangXin Chen
Dec 9, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yuta MyojinTetsuo Takehara
Oct 24, 2020·Journal of Cellular Physiology·Jiayu JinDan Meng
Feb 6, 2021·The American Journal of Pathology·Yi ZhangXin Chen
Mar 4, 2021·Cellular Oncology (Dordrecht)·Ting SunLin Jiao
Feb 20, 2021·OncoTargets and Therapy·Xiaoli Zhang, Ying Zhu
Apr 4, 2021·Biomedicines·Na-Hyun LeeJeongeun Hyun
Jun 16, 2021·The American Journal of Pathology·Xinjun LuJingxiao Wang
Aug 23, 2021·Biomarker Research·Xin QingYewei Zhang
Sep 13, 2021·Biophysical Journal·Kerbaï Saïd ErouméAurélie Carlier
Oct 17, 2021·Cellular and Molecular Gastroenterology and Hepatology·Beatrice FogliaMaurizio Parola

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.