Role of the tumour necrosis family ligand APRIL in solid tumour development: Retrospective studies in bladder, ovarian and head and neck carcinomas

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
P Mhawech-FaucegliaBertrand Huard

Abstract

A proliferation inducing ligand (APRIL) from the tumour necrosis family (TNF) promotes the natural development of solid tumours in pre-clinical models. Here, we studied the role of APRIL in patients with urothelial bladder, epithelial surface ovarian, and head and neck squamous carcinomas. By using immunohistochemistry, we revealed an upregulation of APRIL expression in lesions from a significant subset of patients compared to corresponding healthy tissues. APRIL upregulation was not due to autocrine production by tumour cells, but rather originated from infiltration of APRIL-producing neutrophils. Heparan sulphate proteoglycan (HSPG) efficiently concentrated secreted APRIL in lesions. Despite this retention, in situ APRIL upregulation did not significantly alter disease-free and overall survivals of carcinoma patients in retrospective studies. This indicates that APRIL is not potent enough to promote the development of solid tumour cells under the pressure of chemotherapy.

References

Sep 22, 1998·The Journal of Experimental Medicine·M HahneJ Tschopp
Jul 3, 2002·Nature Reviews. Cancer·Ram SasisekharanUma Narayanasami
Nov 13, 2002·Annual Review of Immunology·Fabienne MackayJeffrey Browning
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Jan 9, 2004·Reproductive Biology and Endocrinology : RB&E·DeannaLee M Beauvais, Alan C Rapraeger
Nov 27, 2004·Current Directions in Autoimmunity·Diane F Jelinek, Jaime R Darce
Apr 23, 2005·Cell Death and Differentiation·J HendriksJ P Medema
Apr 27, 2005·The Journal of Experimental Medicine·Karine IngoldPascal Schneider
Jun 24, 2006·Journal of Leukocyte Biology·P Mhawech-FaucegliaB Huard

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Citations

Jun 19, 2012·Cell Death and Differentiation·V LascanoM Hahne
Mar 18, 2009·BMC Cancer·Jérôme MoreauxBernard Klein
Nov 28, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Meng LianFan Yang
Jan 22, 2009·Médecine sciences : M/S·Maka BurjanadzeBertrand Huard
Mar 17, 2009·Critical Reviews in Oncology/hematology·E RoosnekB Huard
Sep 24, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ru WangJugao Fang
Sep 20, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lin ChenFeng Wang
Feb 16, 2013·Seminars in Cancer Biology·Cristina TecchioMarco A Cassatella
Mar 10, 2015·Carcinogenesis·Araceli García-CastroLourdes Planelles
Apr 17, 2019·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·İlay Berke MenteşeMünci Yağcı
Aug 28, 2021·Cytokine & Growth Factor Reviews·Kinga Henryka Nowacka, Ewa Jabłońska

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