Role of thromboxane A2 in bradykinin-induced human isolated small bronchi contraction

European Journal of Pharmacology
M MolimardC Advenier

Abstract

We previously demonstrated that the bradykinin-induced contraction of human isolated small bronchi is inhibited by indomethacin, capsaicin (N-methyl-N-6-nonenamide) and ruthenium red but not by tachykinin receptor antagonists. The thromboxane A2 receptor (TP receptor) antagonist GR32191 ((1R-(1 alpha(Z),2 beta,3 beta,5 alpha))-(+)-7-(5-(((1,1'-biphenyl)-4-yl)- methoxy)-3-hydroxy-2-(1-piperidinyl)cyclopentyl)-4-heptenoic acid, hydrochloride) (10(-10) to 10(-8) M) dose dependently inhibited the effect of bradykinin, suggesting the mediation of the TP receptor in the action of bradykinin. With higher concentrations of GR32191 (10(-7) and 10(-6) M) bradykinin induced a relaxation which was inhibited by indomethacin and by the bradykinin B2 receptor antagonist Hoe 140 (D-Arg0[Hyp3,Thi-5,D-Tic7,Oic8]bradykinin). The thromboxane A2 synthase inhibitor dazoxiben (4-(-2-(1H-imidazol-1-yl)ethoxy) benzoic acid hydrochloride) 10(-6) M inhibited the bradykinin-induced contraction, suggesting that thromboxane A2 was involved in TP receptor stimulation. The thromboxane A2 mimetic U-46619 (9,11-dideoxy-11 alpha,9 alpha-epoxy-methano-prostaglandin F2 alpha)-induced contraction of human distal bronchi was not inhibited by capsaicin and ruthenium ...Continue Reading

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Citations

Feb 2, 1999·Clinical Reviews in Allergy & Immunology·F Marceau, D R Bachvarov
Sep 28, 1999·European Journal of Pharmacology·E BarchaszC Advenier
Jan 1, 1997·British Journal of Pharmacology·A DendorferP Dominiak
Nov 9, 2002·Autonomic & Autacoid Pharmacology·K M Ellis, J R Fozard
Jan 1, 1997·Fundamental & Clinical Pharmacology·P Devillier, G Bessard
Feb 8, 2003·American Journal of Respiratory and Critical Care Medicine·Arthur N FreedRyoichi Suzuki
Feb 4, 2006·European Journal of Pharmacology·William M AbrahamStephen G Farmer

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