PMID: 7021593Aug 1, 1981Paper

Role of thromboxane and prostacyclin in pulmonary vasomotor changes after endotoxin in dogs

The Journal of Clinical Investigation
C A HalesW D Watkins

Abstract

Cyclooxygenase inhibitors prevent the pulmonary vasomotor changes in response to low-dose endotoxin. We, therefore, explored the role of two highly vasoactive prostanoids, thromboxane A(2), a vasoconstrictor, and prostacyclin, a vasodilator, in the transient pulmonary vasoconstriction and subsequent loss of alveolar hypoxis vasoconstriction (AHPV) that follows endotoxin. AHPV was tested in the dog with a double-lumened endotracheal tube allowing ventilation of one lung with nitrogen as a hypoxic challenge while the other lung was ventilated with oxygen to maintain systemic oxygenation. Relative distribution of perfusion to the two lungs was assessed with intravenous (133)Xe and external scintillation detectors. The stable metabolites of thromboxane and prostacyclin, i.e., thromboxane B(2) and 6-keto-prostaglandin F(1alpha) were measured in plasma with radioimmunoassay. 15 mug/kg i.v. of endotoxin induced no rise in pulmonary vascular resistance (PVR), but prevented AHPV so that the initial 33% (+/-2 SEM) decrease in perfusion to the hypoxic lung became only a 2% (+/-1) decrease. Circulating levels of thromboxane and prostacyclin concurrently rose (P < 0.01) from nondetectable levels to 380 pg/ml (+/-40) and 360 pg/ml (+/-130). ...Continue Reading

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Citations

Aug 1, 1983·Agents and Actions·N Semeraro, A Lattanzio
Jan 1, 1992·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·M FanD X Wang
Jan 1, 1992·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·M FanZ H Zhu
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May 16, 2003·Vascular Pharmacology·A B Johan Groeneveld
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Jun 1, 1994·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J Y JeremyD P Mikhailidis

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