PMID: 377285Apr 1, 1979Paper

Role of Thy-1 antigen in the in vitro differentiation of a rat mammary cell line

Proceedings of the National Academy of Sciences of the United States of America
R DulbeccoM Unger

Abstract

A line of rat mammary cells, LA7, undergoes differentiation into domes or ridges or projections under partial medium control. Immunofluorescent studies show that at the time of dome formation the LA7 cultures express the Thy-1 antigen at the borders between cells. Exposure of the cultures to certain monoclonal anti-Thy-1.1 sera prevents formation of new domes and causes disappearance of preexisting ones; antisera to whole cells produce no visible effect. Cultures exposed to anti-Thy-1 sera at effective concentrations of antibody against domes show morphological changes and ridge formation. It seems that the specific interactions of these antisera with the Thy-1 antigen redirects the differentiation program of the cells.

References

Feb 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·U RutishauserG M Edelman
Oct 1, 1978·European Journal of Immunology·A RaedlerH G Thiele
Dec 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·V A LennonR Dulbecco
Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R DulbeccoM Unger
Sep 1, 1978·Cell·D C BennettP S Rudland
Apr 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·D S MisfeldtD R Pitelka

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Citations

Aug 1, 1983·Biulleten' eksperimental'noĭ biologii i meditsiny·I N Kriukova, S V Litvinov
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R DulbeccoM Unger
Jan 1, 1990·Fundamental & Clinical Pharmacology·P J Neveu, M Le Moal
Oct 12, 1999·American Journal of Reproductive Immunology : AJRI·A BukovskyP P McKenzie
Mar 1, 1989·Environmental Health Perspectives·R Barraclough, P S Rudland
Feb 1, 1981·Analytical Biochemistry·G S Eisenbarth
Apr 15, 1984·International Journal of Cancer. Journal International Du Cancer·I N Kryukova, S V Litvinov
Jul 15, 1983·International Journal of Cancer. Journal International Du Cancer·P HerseyW H McCarthy
Jul 17, 1980·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R Dulbecco, S Okada
Jan 1, 1988·Immunology and Cell Biology·C R ParishI F McKenzie
Jan 1, 1981·Journal of Neuroscience Research·R Akeson, K L Graham

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