Role of thyroid state on induction by ciprofibrate of laurate hydroxylase and peroxisomal enzymes in rat liver microsomes

Biochemical Pharmacology
C PacotN Latruffe

Abstract

The effects of hypothyroidism and hyperthyroidism upon liver microsomal omega-laurate hydroxylase activity (cytochrome P450 IV A1-dependent), peroxisome proliferation marker enzyme activities and acyl CoA oxidase (AOX) expression induced by ciprofibrate (2 mg/kg/day during 8 days) were studied in the male Wistar rat so as to clarify firstly the possible involvement of thyroid hormones in the modification of peroxisomal ciprofibrate-induced enzyme activities in relation to hepatic microsomal cytochrome P450 IV A1 induction, and secondly the possible direct effect of thyroid hormones on the gene expression of specific peroxisomal enzymes. No significant change was found in the ciprofibrate-induced omega-laurate hydroxylase activity in hypothyroid rats or in rats that had received a large dose of triiodothyronine (LT3), suggesting that the thyroid hormone does not interfere with the peroxisome proliferation process through such an indirect mechanism. The induction by ciprofibrate [2-(4-(2-2dichlorocyclopropyl)phenoxyl-2methyl-propion ic acid)] of mitochondrial alpha-glycerolphosphate dehydrogenase and microsomal bilirubin UDPGT was decreased about 3-fold and 1.5-fold, respectively, while the induction of peroxisomal AOX, carnitine...Continue Reading

References

Jun 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·P B Lazarow, C De Duve
Aug 1, 1978·The Journal of Cell Biology·R WattiauxF Dubois
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Jul 27, 1979·Biochemical and Biophysical Research Communications·T Osumi, T Hashimoto
Feb 4, 1992·Biochemical Pharmacology·S Green
Mar 15, 1991·The Biochemical Journal·R HertzJ Bar-Tana
May 1, 1990·Biochimica Et Biophysica Acta·R L Shoemaker, R K Yamazaki
Apr 1, 1987·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S FournelG Siest
Jun 1, 1988·Regulatory Toxicology and Pharmacology : RTP·W T Stott
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J K ReddyN D Lalwani
May 15, 1987·Archives of Biochemistry and Biophysics·F U Hartl, W W Just
Jan 1, 1973·Advances in Clinical Chemistry·K P HeirweghJ Fevery
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D DiMaioT Maniatis
Jan 1, 1964·Hoppe-Seyler's Zeitschrift für physiologische Chemie·P HUEBL, R BRETSCHNEIDER

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