Role of tissue kallikrein-kininogen-kinin pathways in the cardiovascular system

Archives of Medical Research
Jagdish N Sharma

Abstract

All the components of the kallikrein-kinin system are located in the cardiac muscle, and its deficiency may lead to cardiac dysfunction. In recent years, numerous observations obtained from clinical and experimental models of diabetes, hypertension, cardiac failure, ischemia, myocardial infarction and left ventricular hypertrophy have suggested that the reduced activity of the local kallikrein-kinin system may be instrumental for the induction of cardiovascular-related diseases. The cardioprotective property of the angiotensin converting enzyme inhibitors is primarily mediated via kinin-releasing pathway, which may cause regression of the left ventricular hypertrophy in hypertensive situations. The ability of kallikrein gene delivery to produce a wide spectrum of beneficial effects makes it an excellent candidate in treating hypertension, cardiovascular and renal diseases. In addition, stable kinin agonists may also be available in the future as therapeutic agents for cardiovascular and renal disorders.

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Citations

Apr 25, 2012·Inflammopharmacology·Jagdish N Sharma
May 16, 2009·Current Hypertension Reports·Jagdish N Sharma
May 5, 2012·Neurochemistry International·Ibeth Guevara-Lora
Feb 3, 2009·International Journal of Cardiology·Salvatore Patanè, Filippo Marte
Jan 23, 2009·International Journal of Cardiology·Salvatore Patanè, Filippo Marte
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Jun 17, 2015·Bioorganic & Medicinal Chemistry Letters·Adriana F SilvaVani X Oliveira
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Jul 7, 2017·American Journal of Physiology. Endocrinology and Metabolism·María E FrigoletI George Fantus
Jan 17, 2020·Nature Reviews. Nephrology·Sydney C W Tang, Wai Han Yiu

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