Role of titin in vertebrate striated muscle

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
L Tskhovrebova, J Trinick

Abstract

Titin is a giant muscle protein with a molecular weight in the megaDalton range and a contour length of more than 1 microm. Its size and location within the sarcomere structure determine its important role in the mechanism of muscle elasticity. According to the current consensus, elasticity stems directly from more than one type of spring-like behaviour of the I-band portion of the molecule. Starting from slack length, extension of the sarcomere first causes straightening of the molecule. Further extension then induces local unfolding of a unique sequence, the PEVK region, which is named due to the preponderance of these amino-acid residues. High speeds of extension and/or high forces are likely to lead to unfolding of the beta-sandwich domains from which the molecule is mainly constructed. A release of tension leads to refolding and recoiling of the polypeptide. Here, we review the literature and present new experimental material related to the role of titin in muscle elasticity. In particular, we analyse the possible influence of the arrangement and environment of titin within the sarcomere structure on its extensible behaviour. We suggest that, due to the limited conformational space, elongation and compression of the molecu...Continue Reading

References

Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·K WangR Ramirez-Mitchell
Jul 1, 1988·Biophysical Journal·R Horowits, R J Podolsky
Dec 5, 1984·Journal of Molecular Biology·J TrinickA Whiting
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·K WangD Palter
May 1, 1984·Journal of Biochemistry·K MaruyamaM Kikuchi
Oct 1, 1994·Trends in Biochemical Sciences·J Trinick
Nov 22, 1993·Proceedings. Biological Sciences·A SoteriouJ Trinick
Dec 1, 1995·The Journal of Cell Biology·A HoumeidaJ Trinick
Aug 9, 1996·Journal of Molecular Biology·W A LinkeS Labeit
Sep 1, 1996·Circulation Research·M HelmesH Granzier
Mar 1, 1996·Current Biology : CB·J Trinick
Jan 17, 1997·Journal of Molecular Biology·L Tskhovrebova, J Trinick
Apr 1, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K Maruyama
Jun 1, 1997·Journal of Muscle Research and Cell Motility·K TrombitásG H Pollack
Aug 1, 1997·Biophysical Journal·W A LinkeM Gautel
Apr 30, 1998·Physiological Reviews·B M Millman
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·W A LinkeB Kolmerer
Sep 2, 1998·Journal of Structural Biology·M S KellermayerH L Granzier
Nov 25, 1998·Biophysical Journal·W A Linke, H Granzier
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·M Carrion-VazquezJ M Fernandez
Jul 9, 1999·Reviews of Physiology, Biochemistry and Pharmacology·R Horowits
Jul 9, 1999·Reviews of Physiology, Biochemistry and Pharmacology·M GautelP Young
Sep 11, 1999·Trends in Cell Biology·J Trinick, L Tskhovrebova
Dec 10, 1999·Biophysical Journal·K TrombitásH Granzier

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Citations

Feb 13, 2003·Current Opinion in Structural Biology·Andreas Matouschek
Jul 5, 2007·Journal of the Royal Society, Interface·A Luis DorfmannBarry A Trimmer
Feb 12, 2009·Development, Growth & Differentiation·Vyacheslav Dyachuk, Nelly Odintsova
Nov 1, 2003·Proceedings of the National Academy of Sciences of the United States of America·Dietmar LabeitHenk Granzier
Oct 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Christiane A OpitzWolfgang A Linke
Dec 10, 2013·Computational and Mathematical Methods in Medicine·S SchmittD Häufle
Feb 1, 2005·Scandinavian Journal of Medicine & Science in Sports·H KyröläinenP V Komi
Aug 10, 2004·Biophysical Journal·Mark C LeakeRobert M Simmons
Dec 29, 2013·Developmental Biology·J Layne MyhreDavid B Pilgrim
May 1, 2010·Biomolecular Concepts·Paweł PasikowskiZbigniew Szewczuk
Oct 16, 2012·Biophysical Journal·Tamás HuberMiklós S Z Kellermayer
May 12, 2004·Developmental Biology·Scott R MayAndrew S Peterson
Feb 9, 2006·Journal of Muscle Research and Cell Motility·Jeffrey G ForbesKuan Wang
Feb 9, 2006·Journal of Muscle Research and Cell Motility·Larissa TskhovrebovaJohn Trinick
Apr 17, 2004·Circulation Research·John S Walker, Pieter P de Tombe
Feb 14, 2006·Journal of Muscle Research and Cell Motility·Nair PreethaHenk Granzier
Jun 26, 2012·Bioinspiration & Biomimetics·S SchmittM Günther
Mar 12, 2019·Journal of Biomechanics·Timothy R LeonardWalter Herzog
May 27, 2003·Biochimica Et Biophysica Acta·Miklós S Z KellermayerHenk L Granzier
Jul 31, 2010·Accounts of Chemical Research·Hongbin Li, Yi Cao

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