Role of TNF-α polymorphism -308 in neurosensory irritation

International Journal of Cosmetic Science
J A DavisSteven B Hoath

Abstract

Neurosensory cutaneous discomfort in response to topical products is common, yet the relationship between symptoms such as stinging and visible irritation is currently unclear. The presence of a polymorphism at position -308 on the TNF-α gene has been associated with skin irritation, i.e., erythema, dryness. Individuals with a G to A transition (AA/GA genotypes) have a lower threshold to experimentally induced irritation than those with the wild type (G allele, GG genotype). We investigated the effect of this polymorphism on neurosensory irritation (NSI). DNA genotyping was used to determine the allele type amongst a population of health care workers. The neurosensory response to lactic acid and water on the nasolabial folds and hands was assessed using a quantitative lactic acid sting test. Both genotypes had a more intense response to lactic acid compared with water on the face. The AA/GA genotypes had directionally higher scores from lactic acid (P = 0.1) and significantly higher stinging intensities from water (P = 0.001) on the face. For the hands, stinging intensities were higher for lactic acid and water amongst the AA/GA genotypes (P = 0.03 and 0.006 respectively). NSI to lactic acid was significantly higher on the face...Continue Reading

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Citations

Jul 23, 2014·Facial Plastic Surgery Clinics of North America·Marty O VisscherDavid B Hom
Feb 5, 2016·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·L SunY Ma
Jun 14, 2012·International Journal of Cosmetic Science·M O Visscher, R Randall Wickett
Oct 3, 2014·Reviews on Environmental Health·Ting-Shun Wang, Tsen-Fang Tsai

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