PMID: 9438678Jan 23, 1998Paper

Role of TNF-alpha but not NGF in murine hyperalgesia induced by parasitic infection

Psychopharmacology
L AloeM Fiore

Abstract

Using adult mice infected with the trematode Schistosoma mansoni, we observed that this infection induces both thermal hyperalgesia and an increase in the levels of nerve growth factor in the paws. To explore the mechanism involved in peripheral hypersensitivity during chronic infection, mice were infected with 60 cercariae of S. mansoni and injected 17 weeks later with nerve growth factor, anti-nerve growth factor or with other molecules known to be associated with hyperalgesic processes. The results of these studies showed that antibodies against tumor necrosis factor-alpha, but not against nerve growth factor, reduce thermal sensitivity in schistosome infected mice, suggesting that this cytokine but not NGF plays a crucial role in schistosome-induced thermal hyperalgesia. Treatments with anti-inflammatory drugs support this hypothesis.

Citations

Dec 2, 1999·Neuroscience and Biobehavioral Reviews·M KavaliersE Choleris
Nov 7, 2000·Parasitology Today·M KavaliersE Choleris
Feb 13, 1999·Progress in Neurobiology·M J Millan
Apr 6, 2002·Archives of Physiology and Biochemistry·M Fiore, L Aloe
Oct 1, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kenneth LambKlaus Bielefeldt
Feb 24, 2015·Autonomic & Autacoid Pharmacology·K V Viana-CardosoF de A A Gondim
Apr 30, 2020·Current Neuropharmacology·Flavio Maria CeciMarco Fiore

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