Role of TNF receptor-associated factor 2 in the activation of IgM secretion by CD40 and CD120b

The Journal of Immunology : Official Journal of the American Association of Immunologists
B S Hostager, Gail A Bishop

Abstract

TNFR-associated factors (TRAFs) participate in the signaling of many TNFR family members, including CD40, CD120a (TNFR1), and CD120b (TNFR2). Previously, we found that a dominant-negative TRAF2 molecule inhibits CD40-mediated Ab secretion by the mouse B cell line CH12.LX. However, disruption of the TRAF2 binding site in the cytoplasmic domain of CD40 does not diminish the ability of CD40 to stimulate Ab secretion, nor is this mutation able to circumvent the inhibition of Ab secretion by dominant-negative TRAF2. Here we demonstrate that CD40-induced TNF stimulates IgM production through CD120b and that CD120b signaling is required for optimal CD40-induced IgM secretion. Furthermore, although both CD40 and CD120b can bind TRAF2, TRAF2-dependent CD40 signals cannot substitute for TRAF2-dependent CD120b signals in the activation of IgM secretion. Our results indicate a potentially important role for CD120b in the activation of IgM secretion and that TRAF2 is used by CD40 and CD120b in distinct ways.

References

Nov 1, 1991·Clinical Immunology and Immunopathology·B HeiligB Dörken
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G A Bishop, J A Frelinger
Sep 1, 1984·European Journal of Immunology·M Baniyash, Z Eshhar
Aug 1, 1994·European Journal of Immunology·A W HeathM C Howard
Nov 14, 1997·The Journal of Experimental Medicine·J RubyJ J Peschon
Nov 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·G A BishopM A Tomai

❮ Previous
Next ❯

Citations

Sep 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sarah L RowlandBruce S Hostager
Aug 12, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·John P GrahamGail A Bishop
May 11, 2010·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Wen ZhangPeter E Lipsky
Oct 16, 2018·Frontiers in Immunology·Gail A BishopBruce S Hostager
Oct 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sokol A Haxhinasto, Gail A Bishop
Jul 10, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Melissa E MunroeGail A Bishop
Nov 22, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claire M Buchta, Gail A Bishop
Sep 10, 2003·The Journal of Biological Chemistry·Li-Fan LuRandolph J Noelle
Oct 2, 2004·Nature Reviews. Immunology·Gail A Bishop
Aug 24, 2010·Immunological Reviews·John P GrahamGail A Bishop
Apr 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ping XieGail A Bishop
Jul 20, 2007·Journal of Leukocyte Biology·Riad M RahhalGail A Bishop
Nov 3, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anna L Peters, Gail A Bishop
Feb 26, 2004·The Journal of Experimental Medicine·Ping XieGail A Bishop
Jul 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sokol A HaxhinastoGail A Bishop
Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Melissa E Munroe, Gail A Bishop
Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rosa M AndradeCarlos S Subauste
Jun 6, 2003·Cytokine & Growth Factor Reviews·Gail A Bishop, Bruce S Hostager
Dec 6, 2005·Cellular Immunology·Rosa M AspalterMartha M Eibl

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
Carissa R Moore, Gail A Bishop
Current Opinion in Genetics & Development
M Tewari, V M Dixit
The Journal of Immunology : Official Journal of the American Association of Immunologists
S V JalukarGail A Bishop
The Journal of Biological Chemistry
Kevin D BrownGail A Bishop
© 2022 Meta ULC. All rights reserved