Role of TNFSF15 in the intestinal inflammatory response

World Journal of Gastrointestinal Pathophysiology
Tanya KadiyskaAni Chavoushian

Abstract

Gastrointestinal diseases, specifically Crohn's disease, ulcerative colitis, diverticular disease, and primary biliary cirrhosis are all characterized by complicated inflammation of the digestive tract. Their pathology is multifactorial, and risk factors encompass both genetic and environmental factors. Recent advances in the genetic component of inflammatory bowel diseases (IBDs) have revealed that the tumor necrosis factor superfamily member 15 (TNFSF15) contains a number of risk alleles associated not only with IBD but also with other diseases such as diverticular disease and primary biliary cirrhosis. These risk alleles in TNFSF15 and the altered expression of its gene product can serve as the common ground between these disorders by explaining at least some of the underlying processes that lead to a dysregulated immune response and subsequent chronic inflammation. Here, we aim to outline how the TNFSF15 gene is involved in the proliferation and cell fate of different populations of T cells and subsequently in the control of both pro- and anti-inflammatory cytokines. Furthermore, we summarize what is currently known of TNFSF15 control region variants, how they are associated with each mentioned disease, and how these varian...Continue Reading

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Citations

Sep 20, 2020·Nature Communications·Pedram Shafiei-JahaniOmid Akbari
Dec 31, 2020·Pharmacogenomics and Personalized Medicine·Yun-Liang ShenHong-Sheng Wang

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