Role of total parenteral nutrition in the treatment of Crohn's disease

American Journal of Surgery
E ShiloniH R Freund

Abstract

We studied 49 patients with severe nonresponsive Crohn's disease receiving 73 courses of total parenteral nutrition (TPN) for a total of 2,153 days (30 +/- 18 days/admission). Forty-five percent of all courses of TPN resulted in patients not being operated on, whereas 55 percent resulted in surgical intervention. Fifty percent of patients who did not undergo operation initially as a result of a successful course of bowel rest and TPN had surgery within 15.4 +/- 13.9 months, whereas 75 percent of patients operated on immediately after a course of TPN did not need additional surgery during a follow-up of 36.1 +/- 31.2 months. Thus, a total of 80 percent of patients underwent gastrointestinal surgery sometime during the study and follow-up periods. TPN has an important role in replenishment of nutritional deficits and perioperative nutritional support; however, from the results of the present study, it is difficult to advocate it as the sole primary therapy for Crohn's disease.

References

Nov 1, 1978·Canadian Journal of Surgery. Journal Canadien De Chirurgie·D B Allardyce
Nov 1, 1978·Diseases of the Colon and Rectum·F J Harford, V W Fazio
Oct 1, 1976·Diseases of the Colon and Rectum·V W FazioM Brotman
Oct 1, 1976·Diseases of the Colon and Rectum·R E DeanB Barrett
Nov 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·R F KushnerM D Sitrin
May 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·M J OstroK N Jeejeebhoy
Jul 1, 1974·Diseases of the Colon and Rectum·H W EisenbergF L Weakley
Feb 1, 1973·American Journal of Surgery·J E FischerJ A Ryan
Jan 1, 1983·The British Journal of Surgery·J M MüllerH Pichlmaier
Jan 1, 1980·Digestive Diseases and Sciences·C O ElsonI H Rosenberg
Jan 1, 1980·World Journal of Surgery·L P Bos, I T Weterman
Jun 25, 1981·The New England Journal of Medicine·M R LockF L Weakley

❮ Previous
Next ❯

Citations

Jun 18, 1999·Gastroenterology Clinics of North America·P D HanG R Lichtenstein
Jun 6, 2009·World Journal of Gastroenterology : WJG·Corina HartmanRaanan Shamir
Aug 1, 2008·Nutrition Reviews·Denish MoorthyIrwin H Rosenberg
Mar 22, 2007·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Anthony E WiskinRobert M Beattie
Jan 1, 1992·Scandinavian Journal of Gastroenterology. Supplement·G R Greenberg
Apr 1, 1992·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·J H Bodzin
Feb 14, 2002·JPEN. Journal of Parenteral and Enteral Nutrition·UNKNOWN ASPEN Board of Directors and the Clinical Guidelines Task Force
Jul 17, 2019·Intestinal research·Yong Eun ParkJae Hee Cheon
Dec 21, 2013·Scandinavian Journal of Gastroenterology·John K Triantafillidis, Apostolos E Papalois
Apr 1, 1992·Postgraduate Medicine·C C LowenS A McClave

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.