Role of trace amine-associated receptor 1 in nicotine's behavioral and neurochemical effects

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Jian-Feng LiuJun-Xu Li

Abstract

Nicotine addiction and abuse remains a global health issue. To date, the fundamental neurobiological mechanism of nicotine addiction remains incompletely understood. Trace amine-associated receptor 1 (TAAR1) is thought to directly modulate dopaminergic system and are thought to be a neural substrate underlying addictive-like behaviors. We aimed to investigate the role of TAAR1 in nicotine addictive-like behaviors. TAAR1 expression after nicotine treatment was evaluated by western blotting. c-Fos immunofluorescence and in vivo fast-scan cyclic voltammetry were used to examine the activation of brain regions and dopamine release, respectively. We then thoroughly and systematically examined the role of TAAR1 in mediating nicotine-induced sensitization, nicotine discrimination, nicotine self-administration, nicotine demand curve, and the reinstatement of nicotine-seeking. Local pharmacological manipulation was conducted to determine the role of TAAR1 in the nucleus accumbens (NAcs) in the reinstatement of nicotine-seeking. We found that the expression of TAAR1 protein was selectively downregulated in the NAc, with no change in either dorsal striatum or prefrontal cortex. TAAR1 activation was sufficient to block nicotine-induced c-F...Continue Reading

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Citations

May 26, 2018·Expert Opinion on Therapeutic Targets·Michael D SchwartzRaul R Gainetdinov
Nov 2, 2018·Acta Pharmacologica Sinica·Jian-Feng Liu, Jun-Xu Li
Jun 27, 2018·Pharmacological Reviews·Raul R GainetdinovMark D Berry
Apr 24, 2018·Frontiers in Pharmacology·Ilya SukhanovRaul R Gainetdinov
Nov 18, 2019·Cellular and Molecular Neurobiology·Artem DorotenkoIlya Sukhanov
Dec 19, 2019·Cellular and Molecular Neurobiology·Zhengrong Xu, Qian Li
Jan 25, 2020·Cellular and Molecular Neurobiology·Jianfeng LiuJun-Xu Li
May 1, 2021·International Journal of Molecular Sciences·Veronica BegniMarco A Riva

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Methods Mentioned

BETA
genotyping

Software Mentioned

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