Role of tranexamic acid in management of dysfunctional uterine bleeding in comparison with medroxyprogesterone acetate

Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
A KriplaniS Diwakar

Abstract

Currently, tranexamic acid (TXA) is used as 4 g/day in menorrhagia This prospective randomised study included 100 cases to assess efficacy and safety of 2 g/day TXA in dysfunctional uterine bleeding (DUB) vs cyclical 10 mg twice-daily medroxyprogesterone acetate (MPA) for 3 cycles. Follow-ups were made monthly for 3 months during therapy, then 3 months after. Mean pictorial blood loss assessment chart (PBAC) score decreased from 356.9 to 141.6 in the TXA group and from the pre-treatment 370.9 to 156.6 with MPA and mean reduction of blood loss was 60.3% with TXA and 57.7% with MPA after 3 months (p < 0.005 in both groups). Lack of response during treatment was seen in three patients (6.1%) TXA and in 13 patients (28.9%) with MPA (p = 0.003). In patients who reported 3 months after stopping the treatment, 66.7% in TXA group and 50% in MPA had recurrence of menorrhagia, (p = 0.155). During the 6 months study period more hysterectomies were performed in the MPA than in the TXA group (17.8% vs 4%; p = 0.002). We conclude that TXA in 2 g/day dosage is an effective and safe option in DUB.

References

Jul 3, 1976·Lancet·E Rydin, P O Lundberg
Feb 1, 1991·The Australian & New Zealand Journal of Obstetrics & Gynaecology·I S Fraser, G McCarron
Dec 1, 1990·British Journal of Obstetrics and Gynaecology·L Birgerson, R Bright-Paul
Nov 1, 1990·The Australian & New Zealand Journal of Obstetrics & Gynaecology·I S Fraser
Aug 1, 1990·British Journal of Obstetrics and Gynaecology·J M HighamR W Shaw
Jan 1, 1990·British Journal of Obstetrics and Gynaecology·R Macdonald
Oct 24, 1970·British Medical Journal·S T CallenderE Cope
Jan 1, 1995·International Journal of Technology Assessment in Health Care·A CoulterM C Rees
May 1, 1995·British Journal of Obstetrics and Gynaecology·J T PrestonS K Smith
Aug 15, 2000·Baillière's Best Practice & Research. Clinical Obstetrics & Gynaecology·G A Irvine, I T Cameron
Jun 17, 2000·Obstetrics and Gynecology Clinics of North America·M G Munro
Jun 27, 2003·Drugs·Keri Wellington, Antona J Wagstaff

❮ Previous
Next ❯

Citations

Nov 3, 2012·Archives of Gynecology and Obstetrics·Hatem Abu Hashim
Apr 19, 2013·Archives of Gynecology and Obstetrics·Azita GoshtasebiSamira Behboudi Gandevani
Jul 15, 2009·Journal de gynécologie, obstétrique et biologie de la reproduction·O Graesslin, E Derniaux
Sep 8, 2012·International Journal of Women's Health·Henri Leminen, Ritva Hurskainen
Sep 24, 2011·Journal of Women's Health·Måns Edlund
Jan 7, 2015·Thrombosis Research·Lilian TengbornErik Berntorp
Dec 26, 2009·Best Practice & Research. Clinical Obstetrics & Gynaecology·Efthimios Deligeoroglou, Pandelis Tsimaris
Sep 12, 2009·Fertility and Sterility·Anna TorresEwa Wozniakowska
Jan 11, 2012·Acta Obstetricia Et Gynecologica Scandinavica·Becky Naoulou, Ming C Tsai
Jul 20, 2012·The Annals of Pharmacotherapy·Sandra L Hrometz
Apr 16, 2018·The Cochrane Database of Systematic Reviews·Alison C Bryant-SmithMartha Hickey
Apr 10, 2019·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Lawrence B AfrinShanda R Dorff
Jul 1, 2013·Expert Review of Endocrinology & Metabolism·Anita L Nelson
Apr 26, 2019·Current Opinion in Obstetrics & Gynecology·Jordan S KlebanoffGaby N Moawad
Aug 20, 2019·The Cochrane Database of Systematic Reviews·Magdalena Bofill RodriguezIain T Cameron
Apr 18, 2009·Anesthesia and Analgesia·Richard S GistYaakov Beilin
Dec 1, 2010·Hormone Molecular Biology and Clinical Investigation·Réne Druckmann
Feb 12, 2015·Obstetrical & Gynecological Survey·Johannes BitzerIan S Fraser
Oct 20, 2020·Expert Opinion on Drug Safety·Manuel Luque-RamírezHéctor F Escobar-Morreale

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.