Role of transarterial chemoembolization for hepatocellular carcinoma before liver transplantation with special consideration of tumor necrosis

Clinical Transplantation
André SchaudtMarkus Golling

Abstract

Several authors suggest that local ablative therapies, specifically transarterial chemoembolization (TACE), may control tumor progression of hepatocellular carcinoma (HCC) in patients who are on the waiting list for liver transplantation (orthotopic liver transplantation, OLT). There is still no evidence if TACE followed by OLT is able to prevent recurrence of tumor, to prolong survival rate of the patients on the waiting list, or to improve the survival after OLT. We report 27 patients with HCC who underwent OLT. From these patients, 15 were pre-treated with TACE alone or in combination with percutaneous ethanol injection (PEI) or laser-induced thermo therapy (LITT). Mean time on the waiting list was 214 d for treated patients and 133 d for untreated patients. Comparing pre-operative imaging and histopathological staging post-transplant, we found 13 patients with tumor progression out of which five were treated with TACE. In two of the TACE patients a decrease of lesions could be achieved. In a single patient, there was no evidence of any residual tumor. Only one patient displayed tumor progression prior to OLT despite undergoing TACE. Comparison of outcome in patients undergoing TACE or having no TACE was not statistically si...Continue Reading

References

Nov 14, 1985·The New England Journal of Medicine·C NiederauG Strohmeyer
Mar 14, 1996·The New England Journal of Medicine·V MazzaferroL Gennari
Mar 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S BrunoM U Mondelli
Jan 1, 1997·Digestion·M P Manns, S Kubicka
Aug 6, 1998·Gut·S P Pereira, R Williams
Nov 28, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S AriiR Yamada
Jun 8, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F Y YaoJ P Roberts
Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·D M ParkinP Pisani
May 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chung-Mau LoJohn Wong
Oct 3, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Francis Y YaoJohn P Roberts
Jun 5, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ivo W GraziadeiWolfgang Vogel
Sep 13, 2003·World Journal of Gastroenterology : WJG·Jun QianThomas Vogl
Dec 12, 2003·Lancet·Josep M LlovetJordi Bruix
Mar 12, 2004·Transplantation Proceedings·V StadlbauerK H Tscheliessnigg
Mar 16, 2004·Clinical Transplantation·Linda L WongLivingston Wong
Aug 11, 2004·Archives of Surgery·E William JohnsonRaymond S Yeung
Oct 28, 2004·Gastroenterology·Jayant A Talwalkar, Gregory J Gores
Oct 28, 2004·Gastroenterology·Tae-Jin SongYuman Fong
Apr 14, 2005·European Journal of Gastroenterology & Hepatology·Josep M Llovet, Margarita Sala
Apr 15, 2005·Journal of Gastroenterology·Josep M Llovet
May 5, 2005·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·S HerberM B Pitton
Jun 24, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Thomas DecaensChristophe Duvoux

❮ Previous
Next ❯

Citations

Apr 11, 2012·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Karim M EltawilMichele Molinari
Feb 5, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michael D KlugerJean C Emond
Nov 6, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Eleonora TerziJulie K Heimbach

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Related Papers

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Shin HwangGi-Won Song
Surgery Today
Sung Gyu LeeDong Hwan Chung
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Shin HwangD G Kim
© 2022 Meta ULC. All rights reserved