Role of Transbronchial Lung Cryobiopsies in Diffuse Parenchymal Lung Diseases: Interest of a Sequential Approach

Pulmonary Medicine
Benjamin BondueDimitri Leduc

Abstract

Background. Transbronchial lung cryobiopsies (TBLCs) are a promising diagnostic tool in the setting of diffuse parenchymal lung diseases (DPLDs). However, no comparison with surgical lung biopsy (SLB) in the same patient is available. Methods. The diagnostic yield and safety data of TBLCs, as well as the result of SLB performed after TBLCs, were analysed in a multicentric Belgian study. A SLB was performed after TBLCs in absence of a definite pathological diagnosis or if a NSIP pattern was observed without related condition identified following multidisciplinary discussion. Results. Between April 2015 and November 2016, 30 patients were included. Frequent complications included pneumothorax (20%) and bleeding (severe 7%, moderate 33%, and mild 53%). There was no mortality. The overall diagnostic yield was 80%. A SLB was performed in six patients (three without definite histological pattern and three with an NSIP). The surgical biopsy changed the pathological diagnosis into a UIP pattern in five patients and confirmed a NSIP pattern in one patient. Conclusion. TBLCs are useful in the diagnostic work-up of DPLDs avoiding a SLB in 80% of the patients. However, surgical biopsies, performed as a second step after TBLCs because of an...Continue Reading

References

Nov 24, 2001·American Journal of Respiratory and Critical Care Medicine·K R FlahertyF J Martinez
Apr 5, 2008·American Journal of Respiratory and Critical Care Medicine·William D TravisAthol Wells
Feb 28, 2009·Respiration; International Review of Thoracic Diseases·Alexander BabiakMartin Hetzel
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuUNKNOWN ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis
Jun 18, 2011·Diagnostic Pathology·Sergej GriffWolfram Grüning
Sep 17, 2013·American Journal of Respiratory and Critical Care Medicine·William D TravisUNKNOWN ATS/ERS Committee on Idiopathic Interstitial Pneumonias
Nov 23, 2013·PloS One·Jonathan A KropskiOtis B Rickman
Mar 14, 2014·General Thoracic and Cardiovascular Surgery·Makoto SonobeMichiaki Mishima
Apr 23, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·Oren FruchterMordechai R Kramer
Jun 4, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·Virginia PajaresAlfons Torrego
Mar 19, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Oormila GanganahYi Shi Li
Jul 29, 2016·Annals of the American Thoracic Society·Kerri A JohannsonChristopher J Ryerson
Aug 16, 2016·QJM : Monthly Journal of the Association of Physicians·C SharpA R Medford
Sep 3, 2016·Archives of Pathology & Laboratory Medicine·Thomas V ColbyVenerino Poletti
Nov 2, 2016·The European Respiratory Journal·John P HutchinsonRichard B Hubbard

❮ Previous
Next ❯

Citations

Jun 15, 2018·Journal of Bronchology & Interventional Pulmonology·Jaskaran SethiAli Musani
Aug 24, 2019·American Journal of Respiratory and Critical Care Medicine·Antoine FroidureBenjamin Bondue
Nov 21, 2018·Respirology Case Reports·Marta ZajaczkowskaJonathan Williamson
Jul 25, 2020·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuKevin C Wilson
Apr 23, 2020·Archives of Pathology & Laboratory Medicine·Mitra MehradAlberto Cavazza
Jul 1, 2020·Journal of Bronchology & Interventional Pulmonology·Justin Seashore, Shawn P E Nishi
Apr 28, 2021·BMC Pulmonary Medicine·Benjamin BondueDimitri Leduc
May 8, 2021·Revue des maladies respiratoires·L Michaux, A Froidure
Aug 17, 2021·Current Opinion in Pulmonary Medicine·Claudia Ravaglia, Andrew G Nicholson
Nov 10, 2021·Current Opinion in Pulmonary Medicine·Claudia Ravaglia, Venerino Poletti

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies
sedation
X-ray
the

Software Mentioned

Erbe

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Bronchology & Interventional Pulmonology
Anuradha RamaswamyJonathan Puchalski
Plućne bolesti : casopis Udruzenja pneumoftiziologa Jugoslavije = the journal of Yugoslav Association of Phthisiology and Pneumology
A DebeljakD Ferluga
© 2022 Meta ULC. All rights reserved