Role of transcription factors in peripheral nerve regeneration.

Frontiers in Molecular Neuroscience
Smriti Patodia, Gennadij Raivich

Abstract

Following axotomy, the activation of multiple intracellular signaling cascades causes the expression of a cocktail of regeneration-associated transcription factors which interact with each other to determine the fate of the injured neurons. The nerve injury response is channeled through manifold and parallel pathways, integrating diverse inputs, and controlling a complex transcriptional output. Transcription factors form a vital link in the chain of regeneration, converting injury-induced stress signals into downstream protein expression via gene regulation. They can regulate the intrinsic ability of axons to grow, by controlling expression of whole cassettes of gene targets. In this review, we have investigated the functional roles of a number of different transcription factors - c-Jun, activating transcription factor 3, cAMP response element binding protein, signal transducer, and activator of transcription-3, CCAAT/enhancer binding proteins β and δ, Oct-6, Sox11, p53, nuclear factor kappa-light-chain-enhancer of activated B cell, and ELK3 - in peripheral nerve regeneration. Studies involving use of conditional mutants, microarrays, promoter region mapping, and different injury paradigms, have enabled us to understand their d...Continue Reading

Citations

May 15, 2012·Cell and Tissue Research·Smriti Patodia, Gennadij Raivich
Nov 13, 2013·Nature Reviews. Neurology·Jami Scheib, Ahmet Höke
Jan 23, 2014·Nature Immunology·Justin I Odegaard, Ajay Chawla
Nov 20, 2013·Experimental Neurology·Jung Eun ShinAaron DiAntonio
Mar 28, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Zhi Yong WangBao Guo Jiang
Jan 10, 2016·Neurobiology of Disease·Pierre-Serge LaunayAnnabelle Reaux Le Goazigo
Sep 23, 2014·Neuroscience·A DeFrancesco-LisowitzR E Zigmond
Jun 21, 2016·Scientific Reports·Sumiko Kiryu-SeoHiroshi Kiyama
Aug 6, 2017·The AAPS Journal·Jelena M Janjic, Vijay S Gorantla
Feb 8, 2020·Annals of Plastic Surgery·Jordi Puente-EspelPetros Konofaos
Jul 16, 2019·The Journal of International Medical Research·Tengfei FuJian Zhang
Jun 11, 2017·Cellular and Molecular Life Sciences : CMLS·Nicolas Tricaud, Hwan Tae Park
Oct 9, 2019·Nature Neuroscience·Ilaria PalmisanoSimone Di Giovanni
Jun 6, 2018·Frontiers in Molecular Neuroscience·Marwa El SouryGiovanna Gambarotta
Feb 28, 2017·Frontiers in Cellular Neuroscience·Sheng YiXiaosong Gu
Sep 13, 2020·Journal of Molecular Neuroscience : MN·Valentina DzreyanAnatoly Uzdensky
Jan 24, 2015·The Journal of Biological Chemistry·Holly A HungJohn Svaren
May 4, 2018·Regeneration·Sukla Ghosh, Subhra Prakash Hui
Aug 23, 2019·Molecular Therapy. Nucleic Acids·Li Zhang, Handong Wang
Jan 1, 2021·Cells·Vasileios KampanisRadhika Puttagunta
Jul 23, 2021·Scientific Reports·Wolfgang Pita-ThomasValeria Cavalli
Nov 9, 2021·Frontiers in Cellular Neuroscience·Mingchao LiXinpeng Dun

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Methods Mentioned

BETA
ubiquitination
acetylation
nuclear translocation
pull-down
GTPase

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