PMID: 9444388Jan 28, 1998Paper

Role of transforming growth factor-beta 1 in fibroblasts derived from normal and hypertrophic scarred skin

Archives of Dermatological Research
L J ZhouF Kaneko

Abstract

In order to elucidate the effect of transforming growth factor beta 1 (TGF-beta 1) on normal dermal fibroblasts (NDF) and on fibroblasts derived from hypertrophic scar (HSF) tissue, we compared proliferation, the levels of TGF-beta 1 protein and mRNA, the activity of type-I collagen synthesis and collagenase, and the response to recombinant human (rh) TGF-beta 1 in cultures of both types of cells which had been simultaneously collected from the same patients. We also studied the effects of anti-TGF-beta 1 antibody on the proliferation of these two types of fibroblasts in culture. In spite of the fact that the growth rate of HSF was higher than that of NDF, NDF proliferation was more sensitive to the concentration of rhTGF-beta 1. With respect to rates of synthesis, the results obtained in both groups revealed that the production of type-I collagen was higher and collagenase activity was lower in culture supernatants of HSF. However, the addition of rhTGF-beta 1 resulted in a decrease in the collagenase/collagen ratio in NDF, but failed to induce any change in this ratio in HSF. In addition, the production of TGF-beta 1 and the expression of TGF-beta 1 mRNA in HSF were greater than in NDF. Furthermore, anti-TGF-beta 1 antibody r...Continue Reading

Citations

Sep 30, 2000·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·L J ZhouI Ono
May 16, 2000·Plastic and Reconstructive Surgery·J R MarcusT A Mustoe
May 1, 2001·Biochemical and Biophysical Research Communications·P HoustonM Braddock
Jul 2, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Kyle M ColemanWilliam P Coleman
Jan 8, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Osman Köse, Ahmad Waseem
Jul 12, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Ju-lin XiePo Liu
Jul 23, 2009·American Family Physician·Gregory Juckett, Holly Hartman-Adams
Aug 22, 2008·Journal of Cutaneous Pathology·Xie Ju-LinHuang Yong
Jun 13, 2020·Scars, Burns & Healing·Rajiv S RaktoeAbdoelwaheb El Ghalbzouri
Jan 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sergei P AtamasBarbara White
Aug 30, 2005·Journal of the American College of Surgeons·Leonard LuThomas A Mustoe

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