Role of transgelin-2 in diabetes-associated pancreatic ductal adenocarcinoma.

Oncotarget
Yan SunYu Hu

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with poor prognosis. Diabetes is a significant risk factor for PDAC and >50% of PDAC patients have concomitant diabetes. How diabetes influences the initiation and progression of PDAC remains elusive. Here, we show that transgelin-2 is dominantly expressed in PDAC tissues compared with adjacent normal tissues. The high level of transgelin-2 indicates poor survival of patients with PDAC. Remarkably, transgelin-2 expression is correlated with diabetic status. Hyperinsulinemia is frequently observed in type 2 diabetes. Our results indicate that upregulation of transgelin-2 is induced by insulin via sterol regulatory element-binding protein (SREBP)-1-mediated transcription in PDAC cells. Transgelin-2 is a novel target of SREBP-1. Our data support a novel mechanism in diabetes-associated PDAC by which transgelin-2 mediates proliferation of PDAC cells upon insulin stimulation. The insulin/SREBP-1/transgelin-2 network should be further explored as a diagnostic marker or a novel therapeutic target for diabetes-associated PDAC.

References

Aug 9, 2005·Gastroenterology·Suresh T ChariGloria M Petersen
Mar 1, 2007·Diabetes Care·Pär StattinRudolf Kaaks
Sep 3, 2008·Cell Metabolism·Thomas PorstmannAlmut Schulze
Jun 18, 2010·CA: a Cancer Journal for Clinicians·Edward GiovannucciDouglas Yee
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jul 13, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Kazumori KawakamiMasayuki Nakagawa
Jun 12, 2012·The Journal of Clinical Investigation·Xiaoping ZhaoFajun Yang
Mar 16, 2013·Journal of Molecular Endocrinology·Marija Trajkovic-ArsicJens T Siveke
Oct 26, 2013·CNS Oncology·Deliang GuoArnab Chakravarti
Nov 7, 2014·BMC Cancer·Michelle T ChanJames D Johnson
Jan 16, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yan SunYu Hu
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Feb 19, 2016·The Journal of Obstetrics and Gynaecology Research·Kazuyuki YakabeNorihiro Sugino
Apr 27, 2016·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Belete Biadgo, Molla Abebe
May 20, 2016·Annual Review of Pathology·Tuo DengWilla A Hsueh

❮ Previous
Next ❯

Citations

Jul 2, 2019·Trends in Biochemical Sciences·Lei-Miao YinYong-Qing Yang

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
transfection
ChIP
proteomic profiling
immunoprecipitation
pancreatectomy
transfections
Assay
scraping

Software Mentioned

SPSS

Related Concepts

Related Feeds

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.