Role of Transient Receptor Potential Canonical Channels in Heart Physiology and Pathophysiology

Frontiers in Cardiovascular Medicine
Hairuo WenLai-Hua Xie

Abstract

Transient receptor potential canonical (TRPC) channels are involved in the regulation of cardiac function under (patho)physiological conditions and are closely associated with the pathogenesis of cardiac hypertrophy, arrhythmias, and myocardial infarction. Understanding the molecular mechanisms and the regulatory pathway/locus of TRPC channels in related heart diseases will provide potential new concepts for designing novel drugs targeting TRPC channels. We will present the properties and regulation of TRPC channels and their roles in the development of various forms of heart disease. This article provides a brief review on the role of TRPC channels in the regulation of myocardial function as well as how TRPC channels may serve as a therapeutic target in heart failure and cardiac arrhythmias including atrial fibrillation.

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Citations

May 14, 2021·International Journal of Immunopathology and Pharmacology·Guangyi BaWeitian Zhang
Jul 25, 2021·International Journal of Molecular Sciences·Natthaphat Siri-AngkulJudith K Gwathmey

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Methods Mentioned

BETA
gene knock-out
transgenic

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