Role of translationally controlled tumor protein in cancer progression.

Biochemistry Research International
Tim Hon Man ChanXin-Yuan Guan

Abstract

Translationally controlled tumor protein (TCTP) is a highly conserved and ubiquitously expressed protein in all eukaryotes-highlighting its important functions in the cell. Previous studies revealed that TCTP is implicated in many biological processes, including cell growth, tumor reversion, and induction of pluripotent stem cell. A recent study on the solution structure from fission yeast orthologue classifies TCTP under a family of small chaperone proteins. There is growing evidence in the literature that TCTP is a multifunctional protein and exerts its biological activity at the extracellular and intracellular levels. Although TCTP is not a tumor-specific protein, our research group, among several others, focused on the role(s) of TCTP in cancer progression. In this paper, we will summarize the current scientific knowledge of TCTP in different aspects, and the precise oncogenic mechanisms of TCTP will be discussed in detail.

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Citations

Jul 31, 2013·PloS One·Mari KaarbøFahri Saatcioglu
Jul 1, 2014·IEEE/ACM Transactions on Computational Biology and Bioinformatics·Minta ThomasBart De Moor
Aug 12, 2015·Archives of Oral Biology·Canussanun JirachotikoonUreporn Kedjarune-Leggat
Oct 30, 2012·Biochimie·Miyoung KimKyunglim Lee
Aug 16, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Virginie BaylotPalma Rocchi
Jul 8, 2017·Proteomes·Ida Pucci-MinafraSalvatore Minafra
Apr 18, 2018·Journal of Cell Science·Borka JojicTorsten Ochsenreiter
Mar 9, 2020·Environmental Pollution·Xuelian YangXing Wang

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Methods Mentioned

BETA
nucleotide exchange
ChIP

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