Role of transport systems in amino acid metabolism: leucine toxicity and the branched-chain amino acid transport systems.

Journal of Bacteriology
S C QuayD L Oxender

Abstract

The livR locus, which leads to a trans-recessive derepression of branched-chain amino acid transport and periplasmic branched-chain amino acid-binding proteins, is responsible for greatly increased sensitivity toward growth inhibition by leucine, valine, and serine and, as shown previously, for increased sensitivity toward toxicity by branched-chain amino acid analogues, such as 4-azaleucine or 5',5',5'-trifluoroleucine. These phenotypes are similar to those of relA mutants; however, the livR mutants retain the stringent response of ribonucleic acid synthesis. However, an increase in the rate of transport or in the steady-state intracellular level of amino acids in the livR strain cannot completely account for this sensitivity. The ability of the LIV-I transport system to carry out exchange of pool amino acids for extracellular leucine is a major factor in leucine sensitivity. The previous finding that inhibition of threonine deaminase by leucine contributes to growth inhibition is confirmed by simulating the in vivo conditions using a toluene-treated cell preparation with added amino acids at levels corresponding to the internal pool. The relationship between transport systems and corresponding biosynthetic pathways is discuss...Continue Reading

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Citations

Jan 2, 2004·Journal of Bacteriology·Takashi KoyanagiHidehiko Kumagai
Jul 5, 2006·Journal of Bioinformatics and Computational Biology·Tarek S NajdiEric D Mjolsness
Aug 24, 2010·Journal of Bacteriology·Sok Ho KimLarry Reitzer
Mar 27, 2015·Molecular Microbiology·Yiling YangVictor Sourjik
Jul 23, 2011·Journal of Industrial Microbiology & Biotechnology·Ji-Cheng WangHe-Ping Zhang
Jan 1, 1977·Journal of Supramolecular Structure·D L OxenderS C Quay
Apr 29, 2008·Applied and Environmental Microbiology·Wook Kim, Stuart B Levy
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Jan 20, 2005·The Journal of Biological Chemistry·Chin-Rang YangG Wesley Hatfield
Feb 18, 2018·Current Opinion in Microbiology·Jerome Wong-NgMassimo Vergassola
Jun 11, 2002·Journal of Molecular Biology·Shaolin Chen, Joseph M Calvo
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Dec 2, 2004·Journal of Molecular Biology·Shaolin ChenJoseph M Calvo
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