Abstract
Preventive intraperitoneal trehalose dimycolate (TDM) treatment of mice, inoculated with encephalomyocarditis (EMC) virus by the same route, caused restriction of virus growth in the peritoneum, which was correlated to IFN production in peritoneal fluids prior to infection. Peritoneal macrophages from TDM-treated mice (TDM-PM) spontaneously secreted IFN-alpha/beta in large amounts. By their supernatants, TDM-PM could transfer an antiviral state against EMC virus to permissive resident peritoneal macrophages from control mice. IFN-alpha/beta produced by TDM-PM was found to be involved in this transfer activity. TDM-PM also exerted a strong antiviral effect on EMC virus-infected L-929 cells, which increased with time and the macrophage-target cell ratio. This activity also occurred by an IFN-alpha/beta-dependent mechanism. These data point to the role of IFN-alpha/beta production prior to EMC virus infection in the antiviral activities of TDM-PM and, more generally, in the outcome of viral infection.
References
Nov 2, 1976·The Journal of Experimental Medicine·I GresserD Brouty-Boyé
Jan 1, 1992·Microbiology and Immunology·K SazakiM Azuma
Nov 1, 1990·Microbial Pathogenesis·L WuK Leary
Nov 1, 1990·Virology·E M CocciaG B Rossi
Sep 1, 1990·American Journal of Otolaryngology·T J Tinghitella
Apr 1, 1985·The Journal of General Virology·B Pozzetto, I Gresser
Apr 1, 1985·The Journal of General Virology·J GalabruA G Hovanessian
Aug 1, 1987·The Journal of General Virology·F BelardelliI Gresser
Mar 1, 1987·The Journal of General Virology·M AzumaT Yoshida
Jul 1, 1986·Medicinal Research Reviews·G LemaireE Lederer
Aug 15, 1984·European Journal of Biochemistry·P J CayleyI M Kerr
Oct 1, 1993·Antiviral Research·E GuillemardA M Quero
Jul 1, 1994·Proceedings of the Society for Experimental Biology and Medicine·D G FischerM Rubinstein
Apr 1, 1993·Immunology Today·A J RamsayI A Ramshaw
Jan 1, 1985·Immunology Today·V Bocci
Citations
Mar 1, 2000·Journal of Neuroimmunology·M E LucaL Nagelkerken
Feb 13, 2002·Microbiology and Immunology·R RyllI Yano
Dec 25, 2012·Infection and Immunity·Kaori SakamotoKyle H Rohde
Sep 17, 2010·Journal of Sports Sciences·Vassilios GourgoulisGeorgios Mavromatis
Jun 27, 2020·Indian Journal of Ophthalmology·Rohit ShettySharon D'Souza
Aug 6, 2020·Journal of Clinical Medicine·Pietro Emanuele NapoliMaurizio Fossarello
Aug 10, 1999·Journal of Virology·E GuillemardS Gessani