PMID: 8585770Oct 1, 1995Paper

Role of trehalose dimycolate-induced interferon-alpha/beta in the restriction of encephalomyocarditis virus growth in vivo and in peritoneal macrophage cultures

Antiviral Research
E GuillemardA M Quero

Abstract

Preventive intraperitoneal trehalose dimycolate (TDM) treatment of mice, inoculated with encephalomyocarditis (EMC) virus by the same route, caused restriction of virus growth in the peritoneum, which was correlated to IFN production in peritoneal fluids prior to infection. Peritoneal macrophages from TDM-treated mice (TDM-PM) spontaneously secreted IFN-alpha/beta in large amounts. By their supernatants, TDM-PM could transfer an antiviral state against EMC virus to permissive resident peritoneal macrophages from control mice. IFN-alpha/beta produced by TDM-PM was found to be involved in this transfer activity. TDM-PM also exerted a strong antiviral effect on EMC virus-infected L-929 cells, which increased with time and the macrophage-target cell ratio. This activity also occurred by an IFN-alpha/beta-dependent mechanism. These data point to the role of IFN-alpha/beta production prior to EMC virus infection in the antiviral activities of TDM-PM and, more generally, in the outcome of viral infection.

References

Nov 1, 1990·Microbial Pathogenesis·L WuK Leary
Sep 1, 1990·American Journal of Otolaryngology·T J Tinghitella
Jul 1, 1986·Medicinal Research Reviews·G LemaireE Lederer
Jul 1, 1994·Proceedings of the Society for Experimental Biology and Medicine·D G FischerM Rubinstein
Jan 1, 1985·Immunology Today·V Bocci

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