Role of TREM-1 in pulmonary tuberculosis patients- analysis of serum soluble TREM-1 levels

Scientific Reports
Jia-Yih FengNien-Jung Chen

Abstract

Triggering receptor expressed on myeloid cells 1 (TREM-1) amplifies inflammatory responses and is upregulated during sepsis and pulmonary infection. The association between serum soluble TREM-1 (sTREM-1) level and pulmonary tuberculosis (PTB) disease deserves investigation. In the present study, patients with PTB, latent TB infection (LTBI), and non-TB, non-LTBI subjects were prospectively enrolled and serum levels of sTREM-1, sTREM-2, and C-reactive protein (CRP) were measured. We correlated serum biomarkers and clinical presentations and treatment outcomes of PTB cases. We also utilized immunohistochemistry (IHC) to visualize TREM-1-expressing cells in lung tissues from PTB patients. A total of 86 PTB, 41 LTBI, and 20 non-TB, non-LTBI subjects were enrolled. Serum levels of sTREM-1 and CRP significantly increased in PTB patients; these higher serum levels were correlated with more advanced involvement in chest films and higher bacteria burden in sputum. In multivariate analysis, serum levels of sTREM-1 >260 pg/mL and CRP >2.6 mg/L were independent predictors for on-treatment mortality. Abundant TREM-1-expressing macrophages were identified in lung tissues from PTB samples. In conclusion, serum levels of sTREM-1 correlated wit...Continue Reading

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Citations

Jun 9, 2020·Mediators of Inflammation·Jiahui Jiang DaojunYu
Oct 14, 2020·Microbes and Infection·Jia-Yih FengNien-Jung Chen
Feb 2, 2021·Critical Reviews in Microbiology·Amanda de Oliveira MatosHelioswilton Sales-Campos
Feb 3, 2021·Virulence·L Bernal-MartínezL Alcazar-Fuoli

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Methods Mentioned

BETA
bronchoalveolar lavage
enzyme-linked
ELISA

Software Mentioned

SPSS

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