Role of TrkB in the anxiolytic-like and antidepressant-like effects of vagal nerve stimulation: Comparison with desipramine

Neuroscience
A P ShahAlan Frazer

Abstract

A current hypothesis regarding the mechanism of antidepressant (AD) action suggests the involvement of brain-derived neurotrophic factor (BDNF). Consistent with this hypothesis, the receptor for BDNF (and neurotrophin 4/5 (NT-4/5)), Tropomyosin-related kinase B (TrkB), is activated in rodents by treatment with classical AD drugs. Vagal nerve stimulation (VNS), a therapy for treatment resistant depression (TRD), also activates TrkB in rodents. However, the role of this receptor in the therapeutic effects of VNS is unclear. In the current study, the involvement of TrkB in the effects of VNS was investigated in rats using its inhibitor, K252a. Anxiolytic-like and AD-like effects were analyzed using the novelty suppressed feeding test (NSFT) and forced swim test (FST), respectively. K252a blocked the anxiolytic-like effect of chronic VNS treatment and the AD-like effect of acute VNS treatment. By contrast, blocking TrkB did not prevent either the anxiolytic-like or AD-like effect of chronic treatment with desipramine (DMI), a selective noradrenergic reuptake inhibitor; it did, however, block the acute effect of DMI in the FST. To examine whether the activation of TrkB caused by either VNS or DMI is ligand-dependent, use was made of...Continue Reading

References

Feb 15, 1978·European Journal of Pharmacology·R D PorsoltM Jalfre
Jan 1, 1988·Psychopharmacology·S R BodnoffM J Meaney
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Jul 1, 1997·Archives of General Psychiatry·R S DumanE J Nestler
Sep 16, 1999·Experimental Neurology·E C Yuen, W C Mobley
Oct 12, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A Russo-NeustadtC W Cotman
Jul 13, 2000·Molecular Psychiatry·B L JacobsF H Gage
Dec 26, 2001·Cytokine & Growth Factor Reviews·Francis S LeeMoses V Chao
May 15, 2002·Trends in Pharmacological Sciences·John F CryanIrwin Lucki
Dec 24, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Haiyun XuXin-Min Li
Oct 18, 2003·Stroke; a Journal of Cerebral Circulation·Elin GustafssonZaal Kokaia
Nov 1, 2003·Science·Laura Helmuth
Apr 16, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stephanie C DulawaRene Hen
Jul 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Lisa M MonteggiaEric J Nestler
May 14, 2005·Neuroscience and Biobehavioral Reviews·Stephanie C Dulawa, Rene Hen
Nov 1, 2005·Behavioural Brain Research·N WongwitdechaS Plasen
Apr 25, 2006·Biological Psychiatry·Ronald S Duman, Lisa M Monteggia
Oct 25, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J Thomas CunninghamAlan Frazer
Jan 8, 2008·Psychological Medicine·T E SchlaepferM Hasdemir
May 16, 2008·Expert Opinion on Therapeutic Targets·Tomi Rantamäki, Eero Castrén
Sep 18, 2010·The International Journal of Neuropsychopharmacology·Nanxin LiShuchang He
Apr 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jody L SwiftJean-Martin Beaulieu
May 5, 2012·Nature Protocols·David A Slattery, John F Cryan
Jun 19, 2012·Progress in Neurobiology·Fabien BoulleDaniel L A van den Hove
Oct 9, 2012·Science·Ronald S Duman, George K Aghajanian
Mar 14, 2013·Medical Devices : Evidence and Research·Scott M BerryA John Rush

❮ Previous
Next ❯

Citations

Jun 7, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Flavia R Carreno, Alan Frazer
Apr 10, 2019·International Journal of Neural Systems·Wouter Van LysebettensRobrecht Raedt
Aug 10, 2018·Psychopharmacology·Lindsey J NobleChrista K McIntyre
Feb 3, 2019·Medical Sciences : Open Access Journal·Alper EvrenselMehmet Emin Ceylan
Jun 19, 2019·Learning & Memory·Lindsey J NobleChrista K McIntyre
Dec 1, 2019·Journal of Affective Disorders·Ezek MathewRimenez R Souza
Mar 28, 2021·Neurobiology of Learning and Memory·Rimenez R SouzaChrista K McIntyre
Apr 25, 2021·Neuroscience and Biobehavioral Reviews·Yue WangAilin Luo
Apr 13, 2021·Experimental Neurology·Rimenez R SouzaMichael P Kilgard

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.