Role of TRPV1 channels in renal haemodynamics and function in Dahl salt-sensitive hypertensive rats.

Experimental Physiology
Jianping Li, Donna H Wang

Abstract

This study tests the hypothesis that dysfunction of transient receptor potential vanilloid type 1 (TRPV1) channels occurs and contributes to the decrease in the glomerular filtration rate (GFR) and sodium/water excretion in Dahl salt-sensitive hypertensive rats. Recirculating Krebs-Henseleit buffer added with inulin was perfused at a constant flow in the isolated kidneys of Dahl salt-sensitive (DS) or Dahl salt-resistant (DR) rats fed a high-salt (HS) or low-salt (LS) diet for 3 weeks. Perfusion pressures (PP) were pre-adjusted to three levels ( approximately 100, approximately 150 or approximately 190 mmHg) with or without phenylephrine. Capsaicin, a selective TRPV1 agonist, in the presence or absence of capsazepine, a selective TRPV1 antagonist, was perfused. Basal GFR, urine flow rate (UFR) and Na(+) excretion (U(Na)V) were significantly lower in DS-HS than in DR-HS, DS-LS and DR-LS rats. Capsaicin caused pressure-dependent decreases in PP and increases in GFR, UFR and U(Na)V in all groups, with less magnitude of decreases in PP and increases in GFR, UFR and U(Na)V in DS-HS than in DR-HS, DS-LS and DR-LS rats. Capsazepine completely blocked the effect of capsaicin on PP, GFR, UFR and U(Na)V in all groups. Thus, these results...Continue Reading

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Citations

Mar 26, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hui WangJames J Galligan
Oct 2, 2009·American Journal of Physiology. Renal Physiology·Youping Wang, Donna H Wang
Jul 20, 2010·American Journal of Nephrology·Chaoqin Xie, Donna H Wang
Nov 3, 2009·European Journal of Pharmacology·Jun Peng, Yuan-Jian Li
Oct 26, 2018·Physiological Reviews·Agustin Gonzalez-VicenteJeffrey L Garvin
Dec 26, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mónica Ríos-SilvaMiguel Huerta
Sep 2, 2020·International Journal of Molecular Sciences·Chien-Lin LuMing-Chieh Ma

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