Abstract
20 subjects (8 men, 12 women) with anaphylactic or urticarial reactions after drug intake were evaluated. Tryptase (TRY) and eosinophil cationic protein (ECP) were determined in serum 2 and 24 h after the allergic episode. Histamine was determined in three sequential urine samples. Results indicated that in the group of subjects evaluated, TRY and histamine were elevated, although in not all cases for both markers. With ECP, no clear association was found either at 2 or 24 h after the allergic episode. These results suggested that mast cells participated in the adverse reactions, but a role for eosinophils could not be established. Further studies need to be undertaken to establish the participation of these cells in immediate reactions to drugs.
Citations
Feb 11, 2000·The Journal of Allergy and Clinical Immunology·C O Bingham, K F Austen
Jun 25, 1999·Allergy·P DemolyJ Bousquet
Jun 26, 2001·Allergy·B LebelP Demoly
Dec 24, 1997·Allergy·E OrdoquiM L Baeza
Apr 8, 2006·International Archives of Allergy and Immunology·P KomerickiW Aberer
Mar 1, 2011·Annales Françaises D'anesthèsie Et De Rèanimation·D Laroche, B Debaene
Dec 1, 2009·Allergologia et immunopathologia·J L Corzo-Higueras
Jun 26, 2003·Allergy·P DemolyB Arnoux
Jul 22, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J R PerkinsJ A Cornejo-Garcia
Jan 26, 2017·Allergy·A MuraroK C Nadeau
Sep 6, 2012·Allergy, Asthma & Immunology Research·Enrique GómezMiguel Blanca
Nov 14, 1997·Allergy·M BlancaA Martínez-Valverde
Jun 26, 2015·Current Opinion in Allergy and Clinical Immunology·Miguel Blanca, Bernard Y-H Thong
Feb 4, 2016·Allergy·N Blanca-LópezG Canto
Aug 9, 2020·Clinical and Molecular Allergy : CMA·Maria Teresa CostantinoAntonino Romano
Sep 7, 2018·Clinical and Molecular Allergy : CMA·Stefania IsolaSebastiano Gangemi
Jul 18, 2021·Journal of Immunological Methods·Knut Brockow