Role of tumor-associated glycoprotein-72 in the progression of endometrial adenocarcinoma: a proposed study

Medical Hypotheses
Ines KristoficDaniel Rukavina

Abstract

Endometrial adenocarcinoma is on the basis of the molecular, immunohistological and clinicopathologic features broadly divided into two groups, referred as type I and type II. Type I appears more frequently and in principle patients have a good prognosis; however a significant number of patients develop local recurrences. We hypothesize that TAG-72, expressed on endometrial carcinoma binds and internalizes endocytic pattern recognition receptors on surrounding tissue antigen presenting cells (dendritic cells and macrophages), powers their anti-inflammatory maturation program and make them capable to elicit or modulated tolerogenic immune response mediated by local T and NK effectors. This could support uncontrolled local tumor growth, deeper tumor invasion into surrounding tissues, frequent local recurrences and/or lymph node metastasis. To test this hypothesis, we propose a semi-quantitative immunohistochemical analysis of TAG-72 expression in endometrial adenocarcinoma samples and to correlate the results with clinical and pathological parameters (age, type and histological grade of the tumor, estrogen and progesterone receptor expression, invasion into the myometrium and capillaries, presence of lymph node metastases, FIGO s...Continue Reading

References

Jul 1, 1992·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·K G OsteenF Gorstein
Dec 20, 1989·Journal of the National Cancer Institute·B C WolfG D Steele
Apr 1, 1993·The Journal of Clinical Endocrinology and Metabolism·B A Lessey, J A Pindzola
Jul 1, 1993·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·A M SchwartzK R Williams
Jul 6, 2000·The American Journal of Pathology·U KämmererJ Dietl
May 18, 2001·Biochemical Society Transactions·J D AplinC J Jones
Jan 11, 2007·Cancer Letters·Moorthy P PonnusamySurinder K Batra
Aug 8, 2007·American Journal of Reproductive Immunology : AJRI·Gordana LaskarinSandra M Blois
Jan 17, 2008·Current Opinion in Obstetrics & Gynecology·Xiaofang Yi, Wenxin Zheng
Apr 15, 2008·American Journal of Reproductive Immunology : AJRI·Gordana LaskarinDaniel Rukavina
Dec 9, 2008·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Rafael MolinaXavier Filella
Mar 24, 2009·Lancet·Louis M WeinerSoldano Ferrone
Oct 31, 2009·The International Journal of Developmental Biology·Judith N BulmerGendie E Lash
Apr 23, 2010·American Journal of Reproductive Immunology : AJRI·Gordana LaskarinDaniel Rukavina
Aug 13, 2010·Medical Hypotheses·G LaskarinD Rukavina
Aug 31, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Victoria MaleAshley Moffett
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Jun 1, 2011·Cancer Immunology, Immunotherapy : CII·Isabel PoschkeRolf Kiessling
Aug 2, 2011·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Huiying HeLongwen Chen
Mar 14, 2012·Gynecologic Oncology·Fernanda MusaKevin Holcomb
Jul 6, 2013·Women's Health·Marina Berbic, Ian S Fraser
Jul 19, 2013·Clinical & Developmental Immunology·Arnela RedzovicDaniel Rukavina

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