Role of tumor cell adhesion and migration in organ-specific metastasis formation

Onkologie
P GassmannJörg Haier

Abstract

To form clinically evident metastases--the main cause of death in cancer patients--, tumor cells (TC) must complete a highly complex series of steps called the metastatic cascade, including local invasiveness, intravasation, circulation, adhesion and extravasation, survival, proliferation and angiogenesis. Since failure of any one of these steps results in metastatic failure, understanding the metastatic cascade may guide us to new therapeutic concepts. Here we review the role of specific TC adhesion and migration processes for organ-selective metastasis formation. TC adhesion in the microvasculature of host organs is a specific and highly regulated process mainly mediated by selectins for TC/endothelial cell binding and by integrins for TC/extracellular matrix interactions. Defined expression of the adhesion molecules and their corresponding ligands in the host organs and on the TC governs organ-selective non-random TC arrest. TC motility and subsequent chemotactically guided extravasation of adherent cells is the second rate-limiting step in organ-specific metastasis formation. Only if cells have completed adhesion and extravasation the growth of micrometastases and finally clinically evident metastases can occur.

References

Nov 1, 1990·Cancer Metastasis Reviews·B U PauliD A Hammer
Oct 1, 1989·Current Opinion in Cell Biology·G L Nicolson
Jan 1, 1988·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·L WeissK V Honn
Jan 1, 1988·British Journal of Cancer·D GlavesL Weiss
Jan 10, 1980·Nature·G Poste, Isaiah J Fidler
Jan 27, 1995·International Journal of Cancer. Journal International Du Cancer·A TözerenS W Byers
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R M LafrenieF William Orr
Jan 1, 1993·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·G K KoukoulisV E Gould
Jul 30, 1993·International Journal of Cancer. Journal International Du Cancer·K IwaiT Yoshiki
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M V Agrez, R C Bates
Mar 8, 1996·The Journal of Biological Chemistry·B Felding-HabermannZ M Ruggeri
Feb 1, 1996·The Journal of Experimental Medicine·L BianconeI Stamenkovic
Jun 1, 1996·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·H LiapisS Kitazawa
Apr 1, 1997·Diseases of the Colon and Rectum·S NakamoriT Irimura
May 16, 1997·International Journal of Cancer. Journal International Du Cancer·P BrodtB A Wolitzky
Jun 20, 1997·International Journal of Cancer. Journal International Du Cancer·J RenkonenR Renkonen
Feb 5, 1998·Biochemical Society Transactions·M I BirdR Malhotra
Oct 7, 1998·International Journal of Cancer. Journal International Du Cancer·M ShoM Miyake
Dec 19, 1998·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·A K BosserhoffR Hein
Nov 17, 1999·Proceedings of the Society for Experimental Biology and Medicine·G J Mizejewski
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·B Felding-HabermannB M Mueller
Jun 8, 2001·Diseases of the Colon and Rectum·Jörg Haier, G L Nicolson
Jul 27, 2001·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Jörg Haier, G L Nicolson
Apr 11, 2002·Nature Cell Biology·Cindy K Miranti, Joan S Brugge
Dec 21, 2002·Differentiation; Research in Biological Diversity·Isaiah J Fidler
Mar 15, 2003·Nature Reviews. Cancer·John D Hood, David A Cheresh
May 24, 2003·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jörg HaierNorbert Senninger
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Olaf R F MookCornelis J F Van Noorden

Citations

May 9, 2006·Cancer Metastasis Reviews·Elena I Deryugina, James P Quigley
Jan 9, 2008·Cancer Metastasis Reviews·Isaac P Witz
Nov 7, 2006·Clinical & Experimental Metastasis·Arianna NicolussiAnna Coppa
Jun 20, 2008·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Yan WuJiawen Li
May 9, 2012·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Zhen-Yu DingYu-Quan Wei
Nov 24, 2011·Endocrine-related Cancer·Sonia D'InzeoAnna Coppa
Jul 25, 2013·Biomechanics and Modeling in Mechanobiology·Peng GuoBingmei M Fu
Mar 31, 2015·Expert Review of Neurotherapeutics·Hui WangMing-Hua Zheng
Dec 1, 2012·International Journal of Oral and Maxillofacial Surgery·F MaschinoP Bravetti
Feb 22, 2012·Biomaterials·Peter M CrapoStephen F Badylak
Sep 28, 2010·Biomaterials·Stephen TotteyStephen F Badylak
Oct 26, 2010·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Y LiS-S Du
Mar 23, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Dalit BarkanAnn F Chambers
May 28, 2008·Experimental Cell Research·E Merit Reyes-Reyes, Steven K Akiyama
Mar 27, 2007·Microvascular Research·Kesato IguchiMasataka Onizuka
Jan 9, 2007·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M SchouJ Rygaard
Oct 15, 2010·Molecular Carcinogenesis·Leigh-Ann MacFarlane, Paul R Murphy
Dec 14, 2011·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Andrew D Hughes, Michael R King
Aug 19, 2007·Seminars in Cell & Developmental Biology·Maria V Barbolina, M Sharon Stack
Mar 21, 2019·Acta Cirúrgica Brasileira·Nihat LaçinMehmet Cudi Tuncer
Jun 18, 2014·Immunology and Cell Biology·Amelie Pajip MegaptcheMargot Zöller
Sep 29, 2017·PloS One·Wenping WangZhenxiang Wang
Jan 1, 2010·Cancers·William E DamskyMarcus Bosenberg
Jun 21, 2013·The American Journal of Clinical Nutrition·Gilda GeorgiBernd Stahl
Feb 17, 2015·Molecular Medicine Reports·Koji HaradaYoshiya Ueyama
Jan 19, 2017·International Journal of Molecular Sciences·Roberto Tamma, Domenico Ribatti
Dec 14, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David PáezHeinz-Josef Lenz

Related Concepts

Cell Adhesion
Cell Communication
Cell Motility
Chemotaxis
Endothelium, Vascular
Neoplasm Metastasis
Malignant Neoplasms
Tissue Specificity
Cytokine

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