Role of tumor cell immune escape mechanisms in cytomegalovirus-mediated oncomodulation

Medicinal Research Reviews
Jindrich CinatlH W Doerr

Abstract

It has been known for a long time that cytomegalovirus (CMV) has evolved mechanisms that allow the escape from the host immune surveillance. In the past, many efforts have been done to elucidate the molecular mechanisms underlying this virus-mediated immune escape and thus virus persistence. However, it is unknown, whether CMV may also impair immune responses directed against tumor cells. This might have severe consequences on tumor progression and may explain the growing evidence for CMV-mediated oncomodulation. This review summarizes recent work on CMV-mediated immune escape mechanisms of tumor cells and oncomodulation and proposes novel aspects that may be important for understanding the CMV-associated tumor progression.

References

Dec 1, 1995·Journal of Virology·H ZhuT Shenk
Jan 3, 1996·International Journal of Cancer. Journal International Du Cancer·J CinatlH W Doerr
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·V S GoldmacherT Chittenden
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·S V KotenkoS Pestka
Jun 3, 2000·Annual Review of Immunology·D TortorellaH L Ploegh
Oct 26, 2000·The Journal of Biological Chemistry·P CasarosaM J Smit
Feb 7, 2001·The EMBO Journal·E W HewittP J Lehner
Feb 15, 2001·The Journal of General Virology·R A JohnsonE S Huang
Jun 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·A SkaletskayaV S Goldmacher
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J CinatlH W Doerr
Aug 11, 2001·Current Opinion in Immunology·B E GewurzH L Ploegh

❮ Previous
Next ❯

Citations

Dec 2, 2009·Medical Microbiology and Immunology·Paul R LübeckHolger F Rabenau
Oct 23, 2010·Medical Microbiology and Immunology·Martin MichaelisJindrich Cinatl
Feb 2, 2013·European Journal of Medical Research·Ren QiZeng Xiao-Feng
Sep 5, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Daniel BenharrochJacob Gopas
Jan 1, 2008·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Cecilia Söderberg-Nauclér
May 4, 2012·The Journal of General Virology·Rachel B GillMark N Prichard
Jul 27, 2018·The Journal of General Virology·Claudia Januário Dos SantosMaria Cristina Carlan da Silva
Oct 8, 2013·Current Opinion in Oncology·Charles S Cobbs
Jul 13, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Cécile CourivaudDidier Ducloux
Mar 13, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Farzaneh Tafvizi, Zahra Tahmasebi Fard
Aug 13, 2021·PloS One·DeVon Hunter-SchlichtingHeather H Nelson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.