Role of tumor necrosis factor-alpha and interferon-gamma in Helicobacter pylori infection

Microbiology and Immunology
Toshiro YamamotoJiro Imanishi

Abstract

Immune responses to Helicobacter pylori infection play important roles in gastroduodenal diseases. The contributions of tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) to the induction of gastric inflammation and to the protection from H. pylori infection were investigated using TNF-alpha geneknockout (TNF-alpha(-/-)) mice and IFN-gamma gene-knockout (IFN-gamma(-/-)) mice. We first examined the colonizing ability of H. pylori strain CPY2052 in the stomach of C57BL/6 wild-type and knockout mice. The number of H. pylori colonized in the stomach of IFN-gamma(-/-) and TNF-alpha(-/-) mice was higher than that of wild-type mice. These findings suggest that TNF-alpha and IFN-gamma may play a protective role in H. pylori infection. Furthermore, we examined the contribution of TNF-alpha and IFN-gamma to gastric inflammation. The CPY2052-infected TNF-alpha(-/-) mice showed a moderate infiltration of mononuclear cells in the lamina propria and erosions in the gastric epithelium as did wild-type mice, whereas the CPY2052-infected IFN-gamma(-/-) mice showed no inflammatory findings even 6 months after infection. These results demonstrate that IFN-gamma may play an important role in gastric inflammation induced by H....Continue Reading

References

Jan 1, 1996·Scandinavian Journal of Gastroenterology. Supplement·J E Crabtree
Dec 1, 1995·Scandinavian Journal of Gastroenterology·Y YamaokaJ Imanishi
Jun 18, 1997·Journal of the National Cancer Institute·R M PeekM J Blaser
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·M W MarinoL J Old
Nov 21, 1998·Gut·H Shirin, S F Moss
Nov 24, 1998·Infection and Immunity·C LindholmA M Svennerholm
Nov 24, 1999·Scandinavian Journal of Gastroenterology·W ChenV S Chadwick
May 12, 2000·Alimentary Pharmacology & Therapeutics·A TakagiT Miwa

❮ Previous
Next ❯

Citations

Mar 20, 2010·Mucosal Immunology·D BimczokL E Smythies
Aug 12, 2010·The Journal of Infectious Diseases·Guillermo I Perez-PerezMartin J Blaser
Oct 6, 2007·Current Opinion in Rheumatology·Esther van de Vosse, Michiel A van Agtmael
Oct 17, 2006·Clinical Microbiology Reviews·Holly M Scott Algood, Timothy L Cover
Dec 25, 2012·Infection and Immunity·Brian M GrayKathryn A Eaton
Apr 14, 2015·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jun Won ParkDae-Yong Kim
Nov 13, 2010·FEMS Immunology and Medical Microbiology·Yinghui ZhaoJihui Jia
Sep 26, 2007·FEMS Immunology and Medical Microbiology·Lourdes Alvarez-ArellanoJavier Torres
Jul 19, 2016·The Journal of Clinical Investigation·Lin DingJuanita L Merchant
Sep 24, 2005·Helicobacter·Henrik Permin, Leif P Andersen
Dec 22, 2006·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Ljiljana OtasevicAleksandra Stankovic
Jan 28, 2020·Annual Review of Immunology·Nicholas M Provine, Paul Klenerman
Jul 29, 2011·Animal Science Journal = Nihon Chikusan Gakkaihō·Shiro Kushibiki
Dec 3, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Romy KaebischMarkus Gerhard
Sep 17, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yu-Chih WangChiou-Feng Lin
May 20, 2016·Medicine·Derya Kivrak SalimInci Süleymanlar
Sep 12, 2017·Helicobacter·Karen RobinsonLeif Percival Andersen
Nov 24, 2020·Frontiers in Cellular and Infection Microbiology·Jinling XieYan Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.